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Tubercidin

Known as: 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, 7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7.beta.-D-ribofuranosyl-, 4-Amino-7.beta.-D-ribofuranosyl-7H-pyrrolo(2, 3-d)pyrimidine 
An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity. Tubercidin is… 
National Institutes of Health

Related topics

Related topics

41 relations

Narrower (27)

1,3-dideazaadenosine1,N6-etheno-2'-deoxytubercidin hemihydrat1-deazaadenosine1-deazatubercidin

Broader (6)

Antibiotics, AntifungalAntibiotics, AntineoplasticAntimetabolites, AntineoplasticAntitubercular Agents
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

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1996
1996
Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity.
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During… 
1987
1987
Adenosine deaminase from Saccharomyces cerevisiae: purification and characterization.
Adenosine deaminase from Saccharomyces Cerevisiae was purified about 1600 fold by salt fractionation, ion exchange and affinity… 
1986
1986
Oligonucleotide duplexes containing inosine, 7-deazainosine, tubercidin, nebularine and 7-deazanebularine as substrates for restriction endonucleases HindII, SalI and TaqI.
Synthetic hexadecanucleotide duplexes containing a single purine nucleotide analogue in the recognition sites of the restriction… 
1985
1985
Isolation and characterization of a novel nucleoside, 7-beta-D-ribofuranosylhypoxanthine, from the urine of a chronic myelogenous leukemia patient.
A novel nucleoside, in the amount of 400 micrograms, was isolated from a 24-h collection of urine of a chronic myelogenous… 
1984
1984
Isomeric N-methyl-7-deazaguanines: synthesis, structural assignment, and inhibitory activity on xanthine oxidase.
The N-methyl isomers of 2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (2a) have been synthesized regiospecifically and… 
1982
1982
Effect of nitrobenzylthioinosinate on the toxicity of tubercidin and ethidium against Trypanosoma gambiense.
The coadministration of tubercidin and ethidium to mice infected with Trypanosoma gambiense gave a better parasite clearance than… 
1981
1981
Treatment of mouse neoplasms with high doses of tubercidin.
Previous studies from this laboratory demonstrated that a potent inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR… 
1981
1981
Favored incorporation of tubercidin in poly(adenylic, 7-deazadenylic acids) and their function as messenger ribonucleic acids in protein synthesis.
The following polynucleotides containing the antibiotic tubercidin (Tu; 4-amino-7-beta-D-ribofuranosylpyrrolo-[2,3-d]pyrimidine… 
1979
1979
Interferon induction: a conformational hypothesis.
The ability of polynucleotides or polynucleotide duplexes such as poly(I).poly(C) to induce interferon production is proposed to… 
1968
1968
Purine nucleosides. XX. The synthesis of 7-beta-D-ribofuranosylpurines from imidazole nucleoside derivatives.