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Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP.
The dideoxy chain termination method using deoxy-7-deazaguanosine triphosphate (dc7GTP) in place of dGTP was found to be very useful and use of dc7G TP is concluded to improve the dide oxygen chain termination process for DNA sequencing. Expand
7-Deaza-2'-deoxyguanosine-5'-triphosphate: enhanced resolution in M13 dideoxy sequencing
Agarose linked adenosine and guanosine-5'-monophosphate; a new general method for the coupling of ribonucleotides to polymers through their cis-diols.
This method of preparing resin linked adenosine and guanosine derivatives should be generally applicable to any Ribonucleoside or ribonucleotide with a cis-diol. Expand
9-(2'-deoxy-β-D-xylofuranosyl)adenine building blocks for solid-phase synthesis and properties of oligo(2'-deoxy-xylonucleotides)
The 9-(2′-deoxy-a-D-threo-pentofuranosyl)adenine (=9-(2′-deoxy-a-D-xylofuranosyl)adeninc, xAd; 2) was protected at its 6-NH2 group with cither a benzoyl (5a) or a (dimethyfamino)methylidcnc (6a)… Expand
Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA
The replacement of the furanose moiety of DNA by a cyclohexene ring gives a new nucleic acid structure: cyclohexene nucleic acids or CeNA. CeNAs can be obtained by the classical phosphoramidite… Expand
Syn-anti conformational analysis of regular and modified nucleosides by 1D 1H NOE difference spectroscopy: a simple graphical method based on conformationally rigid molecules
The 1D 1 H NOE difference spectra of 50 base- and/or sugar-modified nucleosides were measured in (CD 3 ) 2 SO with irradiation of various protons. The resulting NOE data were used for a… Expand
Pyrrolo-dC Metal-Mediated Base Pairs in the Reverse Watson-Crick Double Helix: Enhanced Stability of Parallel DNA and Impact of 6-Pyridinyl Residues on Fluorescence and Silver-Ion Binding.
The silver DNA double helix represents the first example of a ps DNA structure built up of bidentate and tridentate reverse Watson-Crick base pairs stabilized by a dinuclear silver-mediated PyrdC pair. Expand
Nucleosides and oligonucleotides containing 1,2,3-triazole residues with nucleobase tethers: synthesis via the azide-alkyne 'click' reaction.
- Padmaja Chittepu, V. R. Sirivolu, F. Seela
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 September 2008
Melting experiments demonstrated that such 1,2,3-triazole nucleosides have a negative impact on the duplex stability when they are placed opposite to the canonical bases as well as abasic sites, which supports the results of melting experiments. Expand