Tryptophanase

Known as: L-Tryptophan indole-lyase (deaminating), EC 1.13.11.11, Tryptophan Pyrrolase 
An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. It is a pyridoxal-phosphate protein, requiring K… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
The gut contains a large 5-HT pool in enterochromaffin (EC) cells and a smaller 5-HT pool in the enteric nervous system (ENS… (More)
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Highly Cited
2009
Highly Cited
2009
Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH), TPH1 and TPH2. By genetically ablating… (More)
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Highly Cited
2007
Highly Cited
2007
Indoleamine 2,3-dioxygenase (INDO) and tryptophan 2,3-dioxygenase (TDO) each catalyze the first step in the kynurenine pathway of… (More)
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Highly Cited
2005
Highly Cited
2005
Pathogenic Escherichia coli, including enteropathogenic E. coli (EPEC), enterohaemorrhagic E. coli (EHEC), enteroinvasive E. coli… (More)
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Highly Cited
2004
Highly Cited
2004
Markers of the kynurenine pathway were studied in postmortem frontal cortex obtained from individuals with schizophrenia and… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, represents a major candidate in… (More)
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Highly Cited
1991
Highly Cited
1991
Escherichia coli forms three permeases that can transport the amino acid tryptophan: Mtr, AroP, and TnaB. The structural genes… (More)
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1971
1971
Catabolite repression of tryptophanase was studied in detail under various conditions in several strains of Escherichia coli and… (More)
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1969
1969
The distribution of tryptophanase was studied. The highest observed specific activity, mumoles per minute per milligram (dry… (More)
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1965
1965
In 1903 Hopkins and Cole (1) identified tryptophan as the source of indole produced by bacterial cultures. The tryptophan… (More)
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