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Trichodermin

Known as: Trichodermin [Chemical/Ingredient], Trichothec-9-en-4-ol, 12,13-epoxy-, acetate, (4beta)- 
Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and… 
National Institutes of Health

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Papers overview

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1986
1986
Trichodermin esterase activity and trichodermin resistance in Mucor racemosus
Mucor racemosus exhibited inducible phenotypic resistance toward the protein synthesis inhibitor trichodermin. Induction of… 
1982
1982
Enzymes of N-acetylglucosamine metabolism during germ-tube formation in Candida albicans.
The enzymes of N-acetyl-D-glucosamine (GlcNAc) metabolism, GlcNAc-6-phosphate deacetylase and GlcN-6-phosphate deaminase were… 
1980
1980
A trichodermin-resistant mutant of Saccharomyces cerevisiae with an abnormal distribution of native ribosomal subunits.
1. A yeast mutant (CLP-8), resistant at the ribosome level to the trichothecene antibiotic trichodermin, differs from its parent… 
1978
1978
Genetic and biochemical characterization of mutants of CHO cells resistant to the protein synthesis inhibitor trichodermin
Mutants resistant to the protein synthesis inhibitor trichodermin have been selected in Chinese hamster ovary (CHO) cells. The… 
Highly Cited
1977
Highly Cited
1977
Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebine…
Stable mutants resistant to the protein synthesis inhibitors cryptopleurine and tylocrebine can be isolated in Chinese hamster… 
Highly Cited
1976
Highly Cited
1976
Mapping of trichodermin resistance in Saccharomyces cerevisiae: a genetic locus for a component of the 60S ribsomal subunit.
Resistance to the protein synthesis inhibitor trichodermin in Saccharomyces cerevisiae has been studied. A single recessive… 
Review
1976
Review
1976
Initiation of the polypeptide chain by reticulocyte cell-free systems. Survey of different inhibitors of translation.
In order to elucidate the mechanism of action of inhibitors that block the initiation of protein synthesis in mammalian systems… 
Highly Cited
1975
Highly Cited
1975
Regulation of ornithine decarboxylase in 3T3 cells by putrescine and spermidine: indirect evidence for translational control.
Addition of putrescine of spermidine prevents the increase in ornithine decarboxylase activity in cultures of 3T3 cells brought… 
1974
1974
Binding of (acetyl-14C)trichodermin to the peptidyl transferase centre of eukaryotic ribosomes.
The antibiotic trichodermin, an inhibitor of the peptidyl transferase centre of eukaryotic ribosomes, was synthesized… 
1973
1973
Total synthesis of (+)-trichodermin.
The first total synthesis of a member of the antibiotic trichothecane group of sesquiterpenes, trichodermin (12,13… 
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