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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. InExpand
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Aristolochic acid and the etiology of endemic (Balkan) nephropathy
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by its insidiousExpand
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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
OXIDATIVE damage to DNA, reflected in the formation of 8-oxo- 7-hydrodeoxyguanosine (8-oxodG)1,2, may be important in mutagenesis, carcinogenesis and the ageing process3,4. Kuchino et al. studied DNAExpand
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Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.
It has been previously shown both in vivo and in vitro that DNA synthesis past an oxidatively damaged form of guanine, 7,8-dihydro-8-oxoguanine (8-oxoG), can result in the misincorporation of adenineExpand
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Aristolochic acid-associated urothelial cancer in Taiwan
Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation, aristolochicExpand
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Mutagenesis by 8-oxoguanine: an enemy within.
The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatensExpand
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Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediate
Endonuclease VIII (Nei) of Escherichia coli is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Nei shares with formamidopyrimidine‐DNA glycosylase (Fpg) sequence homology and aExpand
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8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.
Substrate specificities of FPG protein (also known as formamidopyrimidine DNA glycosylase) and 8-hydroxyguanine endonuclease were compared by using defined duplex oligodeoxynucleotides containingExpand
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A repair system for 8-oxo-7,8-dihydrodeoxyguanine.
Active oxygen species can damage DNA and may play a role in aging and carcinogenesis. We have tested MutY glycosylase for activity on undamaged mispairs as well as mispairs formed with theExpand
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Structure of Formamidopyrimidine-DNA Glycosylase Covalently Complexed to DNA*
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. The Schiff base intermediate formed during this reaction betweenEscherichia coli FpgExpand
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