Triazolam

Known as: Triazolamum, 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine, Clorazolam 
A triazolobenzodiazepinederivative with sedative-hypnotic property. Triazolam interacts directly with a specific site on the gamma-aminobutyric acid… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
AIM To predict the magnitude of metabolic drug-drug interaction (mDDI) between triazolam and diltiazem and its primary metabolite… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND AND PURPOSE Oxidative stress [i.e. increased levels of reactive oxygen species (ROS)] has been suggested as a… (More)
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Highly Cited
2003
Highly Cited
2003
Midazolam, triazolam (TRZ), testosterone, and nifedipine have all been widely used as probes for in vitro metabolism of CYP3A. We… (More)
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Review
2003
Review
2003
The antituberculosis drug rifampicin (rifampin) induces a number of drug-metabolising enzymes, having the greatest effects on the… (More)
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Highly Cited
2000
Highly Cited
2000
Midazolam (MDZ) and triazolam (TRZ) hydroxylation, reactions considered to be cytochrome P-4503A (CYP3A)-mediated in humans, were… (More)
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Review
1998
Review
1998
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… (More)
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1997
1997
BACKGROUND Triazolam is metabolized predominantly by cytochrome P450 3A4 (CYP3A4). Rifampin (rifampicin) is a potent inducer of… (More)
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Highly Cited
1995
Highly Cited
1995
The purpose of this study was to assess the effect of triazolam (0.25 mg) on apnea duration and the arousal response to airway… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Triazolam is metabolized by CYP3A4 isozyme. Ketoconazole and itraconazole may seriously interact with some of the… (More)
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Highly Cited
1989
Highly Cited
1989
The metabolism of midazolam and triazolam to their 1'-hydroxy and 4-hydroxy metabolites was studied in microsomes of 15 human… (More)
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