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Trehalose-6,6'-Dimycolate

Known as: Trehalose 6,6' Dimycolate 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Cord Factors

Papers overview

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Highly Cited
2013
Highly Cited
2013
C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
Cord factor, also called trehalose-6,6'-dimycolate (TDM), is a potent mycobacterial adjuvant. We herein report that the C-type… Expand
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Highly Cited
2010
Highly Cited
2010
Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent… Expand
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Highly Cited
2009
Highly Cited
2009
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Tuberculosis remains a fatal disease caused by Mycobacterium tuberculosis, which contains various unique components that affect… Expand
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Highly Cited
2009
Highly Cited
2009
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation
Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as… Expand
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Highly Cited
2000
Highly Cited
2000
Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose-6,6'-dimycolate.
Trehalose-6,6'-dimycolate (TDM), or cord factor, is a mycobacterial cell wall component that induces granuloma formation and… Expand
1987
1987
Role of interferon in the augmented resistance of trehalose-6,6'-dimycolate-treated mice to influenza virus infection.
Mice inoculated intravenously with 10 to 100 micrograms trehalose-6,6'-dimycolate in an oil-in-water emulsion (TDM emulsion… Expand
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Highly Cited
1977
Highly Cited
1977
Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets
The intensity of the granulomatous reaction evoked in lungs of mice by trehalose-6,6'-dimycolate administered intravenously in… Expand
1977
1977
Tumor regression after intralesional injection of emulsified trehalose‐6,6′‐dimycolate (cord factor): Efficacy increases with oil concentration
Injection of emulsified trehalose‐6,6′‐dimycolate (TDM), a mycobacterial glycolipid, into transplants of an established… Expand
Highly Cited
1976
Highly Cited
1976
Nonspecific resistance against infection with Salmonella typhi and Salmonella typhimurium induced in mice by cord factor (trehalose-6,6'-dimycolate) and its analogues
Mice pretreated intraperitoneally with trehalose-6,6'-dimycolate (cord factor) were protected against an intraperitoneal… Expand
1973
1973
Granulomatous Hypersensitivity to Trehalose-6,6′-Dimycolate (Cord Factor) in Mice Infected with BCG
Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a… Expand
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