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Trehalose-6,6'-Dimycolate

Known as: Trehalose 6,6' Dimycolate 
 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Cord Factors

Papers overview

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Highly Cited
2013
Highly Cited
2013
C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.
Cord factor, also called trehalose-6,6'-dimycolate (TDM), is a potent mycobacterial adjuvant. We herein report that the C-type… Expand
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Highly Cited
2010
Highly Cited
2010
Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent… Expand
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Highly Cited
2009
Highly Cited
2009
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Tuberculosis remains a fatal disease caused by Mycobacterium tuberculosis, which contains various unique components that affect… Expand
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Highly Cited
2009
Highly Cited
2009
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation
Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as… Expand
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Highly Cited
2000
Highly Cited
2000
Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose-6,6'-dimycolate.
Trehalose-6,6'-dimycolate (TDM), or cord factor, is a mycobacterial cell wall component that induces granuloma formation and… Expand
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Highly Cited
1994
Highly Cited
1994
Extravascular coagulation and fibrinolysis in murine lung inflammation induced by the mycobacterial cord factor trehalose-6,6'-dimycolate.
Diffuse pulmonary inflammation in interstitial lung diseases is associated with increased coagulation in the extravascular spaces… Expand
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1977
1977
Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.
The intensity of the granulomatous reaction evoked in lungs of mice by trehalose-6,6'-dimycolate administered intravenously in… Expand
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1977
1977
Tumor regression after intralesional injection of emulsified trehalose‐6,6′‐dimycolate (cord factor): Efficacy increases with oil concentration
Injection of emulsified trehalose‐6,6′‐dimycolate (TDM), a mycobacterial glycolipid, into transplants of an established… Expand
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1976
1976
Nonspecific resistance against infection with Salmonella typhi and Salmonella typhimurium induced in mice by cord factor (trehalose-6,6'-dimycolate) and its analogues.
Mice pretreated intraperitoneally with trehalose-6,6'-dimycolate (cord factor) were protected against an intraperitoneal… Expand
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1973
1973
Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.
Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a… Expand
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