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Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial–mesenchymal transition (EMT) to mesenchymal–epithelial transition (MET) states

Eribulin exerted significant effects on EMT/MET-related pathway components in human breast cancer cells in vitro and in vivo, consistent with a phenotypic switch from mesenchymal to epithelial states, and corresponding to observed decreases in migration and invasiveness in vitro as well as experimental metastasis in vivo.
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Mouse Toll-like Receptor 4·MD-2 Complex Mediates Lipopolysaccharide-mimetic Signal Transduction by Taxol*

It is demonstrated that coexpression of mouse TLR4 and mouse MD-2 is required for Taxol responsiveness and that theTLR4·MD-2 complex is the shared molecule in Taxol and LPS signal transduction in mice.
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Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors.

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Difference in transcriptional regulatory function between c-Fos and Fra-2.

Analysis of chimeric proteins between c-Fos and Fra-2 indicated that this difference is mainly attributable to their C terminal-half regions, which greatly expand the potential range of regulatory functions of the Fos family proteins.
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Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors

Data indicate that the reduction of Spred expression in HCC is one of the causes of the acquisition of malignant features and could be not only a novel prognostic factor but also a new therapeutic target for human HCC.
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Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis.

It is shown that the mRNA for the endogenous cytokine signaling repressor CIS3/SOCS3 is abundantly expressed in RA patients, and induction of CIS3 could represent a new approach for effective treatment of RA.
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Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

A novel role is provided in HCC development: in addition to the previously characterized oncogenic potentials, STAT3 enhances hepatic fibrosis through the upregulation of TGF-β1 expression, and SOCS3 prevents this process.
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Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice.

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Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors.

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Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin.

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