• Publications
  • Influence
Biochemistry of the natural pigments.
  • E. Lederer
  • Biology, Medicine
  • Annual review of biochemistry
  • 1948
Reading is a need and a hobby at once and this condition is the on that will make you feel that you must read. Expand
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.
Further structural simplifications of the active molecule are reported; natural N-acetyl-muramyl-tripeptides have been found active and the smallest adjuvant molecule found is a synthetic N- acetyl muramyl -dipeptide prepared by Sinay et al. Expand
Biotransformation of perchloroethene: dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation.
The obtained data suggest that glutathione conjugate formation and beta-lyase-dependent bioactivation of TCVC in PER metabolism is significantly higher in rats than in humans, and using rat tumorigenicity data for human risk assessment of PER exposure may overestimate human tumor risks. Expand
The chemical structure of the cord factor of Mycobacterium tuberculosis.
The chemical structure of cord factor of Mycobacterium tuberculosis has been established as trehalose-6,6'-dimycolate (I), C186H366O17±10CH2, and methylation studies show that the two mycolic acid molecules are attached through an ester linkage to the primary hydroxyl groups oftrehalose. Expand
Structure of the Mycolic Acids of Mycobacteria
The structural features of mycolic acid, as elucidated by J.R. Anderson1, are as follows: its probable formula is C88H176O4, with one—COOH, one—OH and one—OCH3 group. Expand
Occurrence of N-glycolylmuramic acid in bacterial cell walls. A preliminary survey.
The N-acyl substituent of muramic acid in the cell walls of some species of Actinomycetales and of the related family of Corynebacteriaceae has been studied. The N-glycolyl derivative, recentlyExpand
Adjuvant activity of monomeric bacterial cell wall peptidoglycans.
The simplest fragment tested — the disaccharide tetrapeptide (I) — increases circulating antibodies to ovalbumin and induces a delayed hypersensitivity toward this antigen, indicating the immunoadjuvant activity of soluble cell wall peptidoglycans is a property of the monomeric unit and is not restricted to acid fast bacteria. Expand
The mycobacterial cell wall
  • E. Lederer
  • Chemistry, Medicine
  • Pure and applied chemistry. Chimie pure et…
  • 1971
The chemistry of a very complex and most fascinating natural macromolecule: the cell wall of Mycobacteria and related organisms, which contains lipids, peptides and carbohydrates is summarized and the biological activities of mycobacterial cell walls and their components are considered. Expand
Natural and synthetic trehalose diesters as immunomodulators