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The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or… Expand In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To… Expand Understanding the molecular mechanisms that regulate cellular proliferation and differentiation is a central theme of… Expand Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of… Expand Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target… Expand Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG… Expand CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing. Differences in DNA… Expand DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation… Expand Control elements of the tetracycline-resistance operon encoded in Tn10 of Escherichia coli have been utilized to establish a… Expand The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of… Expand