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Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF
The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have clonedExpand
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Negative regulation of Armadillo, a Wingless effector in Drosophila.
Drosophila Armadillo and its vertebrate homolog beta-catenin play essential roles both in the transduction of Wingless/Wnt cell-cell signals and in the function of cell-cell adherens junctions.Expand
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Drosophila Tcf and Groucho interact to repress Wingless signalling activity
Wingless/Wnt signalling directs cell-fate choices during embryonic development,. Inappropriate reactivation of the pathway causes cancer. In Drosophila, signal transduction from Wingless stabilizesExpand
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Cell Division Requires a Direct Link between Microtubule-Bound RacGAP and Anillin in the Contractile Ring
The mitotic microtubule array plays two primary roles in cell division. It acts as a scaffold for the congression and separation of chromosomes, and it specifies and maintains the contractile-ringExpand
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Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
Proper positioning of mitotic spindles ensures equal allocation of chromosomes to daughter cells. This often involves interactions between spindle and astral microtubules and cortical actin. In yeastExpand
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Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis
The tumor suppressor adenomatous polyposis coli (APC) negatively regulates Wingless (Wg)/Wnt signal transduction by helping target the Wnt effector β-catenin or its Drosophila homologue ArmadilloExpand
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Genetic control of cuticle formation during embryonic development of Drosophila melanogaster.
The embryonic cuticle of Drosophila melanogaster is deposited by the epidermal epithelium during stage 16 of development. This tough, waterproof layer is essential for maintaining the structuralExpand
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Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo.
Active endocytotic processes are required for the normal distribution of Wingless (Wg) protein across the epidermal cells of each embryonic segment. To assess the functional consequences of thisExpand
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Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos.
Each segment of a Drosophila larva shows a precisely organized pattern of cuticular structures, indicating diverse cellular identities in the underlying epidermis. Mutations in the segment polarityExpand
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Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila
Adenomatous polyposis coli (APC) is mutated in colon cancers. During normal development, APC proteins are essential negative regulators of Wnt signaling and have cytoskeletal functions. ManyExpand
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