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Topotecan

Known as: Topotecane, Topotecan Lactone, 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan… 
National Institutes of Health

Related topics

Related topics

32 relations

Broader (2)

CamptothecinTopoisomerase I Inhibitors
Carcinoma, Small CellIn BloodLactationNCIt Antineoplastic Agent Terminology

Narrower (6)

HycamtamineHycamtinNSC-609699SK&F-104864-A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse: successful maintenance of durable remission
WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse… 
Highly Cited
2006
Highly Cited
2006
Synthesis of quantum dot-tagged submicrometer polystyrene particles by miniemulsion polymerization.
Submicrometer fluorescent polystyrene (PS) particles have been synthesized via miniemulsion polymerization using CdSe/ZnS core… 
Highly Cited
2006
Highly Cited
2006
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
BACKGROUND 7-Hydroxystaurosporine (UCN-01) inhibits serine-threonine kinases including the Ca2+ and phospholipid-dependent… 
Highly Cited
2005
Highly Cited
2005
Antivascular Therapy for Orthotopic Human Ovarian Carcinoma through Blockade of the Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptors
Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth… 
Highly Cited
2004
Highly Cited
2004
Efficient Inverse Auger Recombination at Threshold in CdSe Nanocrystals
We apply the semiempirical nonlocal pseudopotential method to the investigation of prospects for direct carrier multiplication… 
Highly Cited
2004
Highly Cited
2004
Combination of a CpG-oligodeoxynucleotide and a topoisomerase I inhibitor in the therapy of human tumour xenografts.
Review
2002
Review
2002
Ovarian cancer: progress and continuing controversies in management.
Highly Cited
2000
Highly Cited
2000
Phase I pharmacologic study of oral topotecan and intravenous cisplatin: sequence-dependent hematologic side effects.
PURPOSE In in vitro studies, synergism and sequence-dependent effects were reported for the combination of topotecan and… 
Highly Cited
1998
Highly Cited
1998
Synergistic interactions of combinations of topotecan with standard drugs in primary cultures of human tumor cells from patients
AbstractObjective: Combination therapies are important in the treatment of many tumor types. This study was undertaken to find… 
Highly Cited
1982
Highly Cited
1982
Spectrophotofluorimetric determination of terbium, europium and samarium with pivaloyltrifluoroacetone and tri-n-octylphosphine oxide in micellar solution of nona-oxyethylene dodecyl ether.
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