Topotecan

Known as: Topotecane, Topotecan Lactone, 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To explore this role, we generated Mrp4… (More)
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Highly Cited
2004
Highly Cited
2004
Imatinib mesylate (Gleevec, STI571) is a kinase inhibitor selective for Bcr-Abl, activated c-Kit kinases, and platelet-derived… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE We discovered that breast cancer resistance protein (BCRP), a recently identified adenosine triphosphate-binding cassette… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE To compare the efficacy and safety of pegylated liposomal doxorubicin (PLD) and topotecan in patients with epithelial… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND AND METHODS Breast cancer resistance protein (BCRP/MXR/ABCP) is a multidrug-resistance protein that is a member of the… (More)
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Highly Cited
1999
Highly Cited
1999
Topotecanor mitoxantrone-selected cell lines (T8 and MX3, respectively), derived from the human IGROV1 ovarian cancer cell line… (More)
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Highly Cited
1999
Highly Cited
1999
Mouse fibroblast cell lines lacking functional Mdr1a, Mdr1b, and Mrp1 genes were selected for resistance to topotecan… (More)
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Highly Cited
1999
Highly Cited
1999
Epidermal growth factor (EGF)-related proteins such as transforming growth factor alpha (TGF-alpha) control cancer cell growth… (More)
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Highly Cited
1997
Highly Cited
1997
PURPOSE Topotecan and paclitaxel were evaluated in a randomized, multicenter study of patients with advanced epithelial ovarian… (More)
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Highly Cited
1992
Highly Cited
1992
PURPOSE A phase I and pharmacologic study was undertaken to determine the maximum-tolerated dose (MTD), describe the principal… (More)
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