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Topotecan

Known as: Topotecane, Topotecan Lactone, 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan… 
National Institutes of Health

Related topics

Related topics

32 relations

Broader (2)

CamptothecinTopoisomerase I Inhibitors
Carcinoma, Small CellIn BloodLactationNCIt Antineoplastic Agent Terminology

Narrower (6)

HycamtamineHycamtinNSC-609699SK&F-104864-A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Ligand Exchange Dynamics and Temperature Effects upon Formation of Nanocomposites Based on Semiconductor CdSе/ZnS Quantum Dots and Porphyrins: Ensemble and Single Object Measurements
Dye molecules with pyridyl side substituents (porphyrins and heterocyclic perylene diimides) coordinatively attached to… 
2008
2008
Phase II prospective study of weekly topotecan and bevacizumab in platinum refractory ovarian cancer or peritoneal cancer (OC)
5551 Background: Patients (pts) with platinum refractory OC have limited treatment options. Bevacizumab, an anti- angiogenesis… 
2005
2005
A Phase II trial of paclitaxel and topotecan with filgrastim in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma
Purpose: Therapy for high-grade gliomas remains unsatisfactory. Paclitaxel and topotecan have separately demonstrated activity… 
2003
2003
Stringing up the Pearls: Self-Assembly, Optical and Electronic Properties of CdSe− and Au−LiMo3Se3 Nanoparticle−Nanowire Composites
Chevrel-type LiMo3Se3 nanowires dissolved in dimethyl sulfoxide were decorated with 13 nm citrate ligated Au particles (water… 
2003
2003
Photoionization of individual CdSe/CdS core/shell nanocrystals on silicon with 2-nm oxide depends on surface band bending
CdSe/CdS nanocrystals are studied by electrostatic force microscopy (EFM) on n- and p-type silicon with 2-nm surface oxide and… 
2002
2002
Stripping of Uranium from D2EHPA/TOPO Solvent by Ammonium Carbonate Solutions
Uranium is recovered from phosphoric acid by the D2EHPA/TOPO process. In this process uranium is stripped from the loaded D2EHPA… 
2001
2001
Long time therapy with topotecan in patients with recurrence of ovarian carcinoma.
BACKGROUND In several phase II and III topotecan studies the large number of patients with stable disease is striking. Since no… 
2001
2001
Phase I Clinical Trial of Weekly Combined Topotecan and Irinotecan
&NA; Combining antineoplastic analogues may increase efficacy by increasing the serum and intracellular concentration of the… 
2000
2000
Cytotoxic Effects of Topotecan Combined with Various Active G2/M-Phase Anticancer Drugs in Human Tumor-Derived Cell Lines
Topotecan (TPT) is a DNA-Topoisomerase I poison that exhibitsantitumor activity. TPT, like other DNA-damaging agents, arrests… 
2000
2000
Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan
The illudin derivative MGI 114 (6-hydroxymethylacylfulvene or HMAF) is currently in phase II chemotherapeutic clinical trials for… 
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