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Topotecan

Known as: Topotecane, Topotecan Lactone, 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin 
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Natural resources continue to be an invaluable source of new, novel chemical entities of therapeutic utility due to the vast… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To explore this role, we generated… Expand
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Review
2003
Review
2003
Observations of functional adenosine triphosphate (ATP)-dependent drug efflux in certain multidrug-resistant cancer cell lines… Expand
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Highly Cited
2002
Highly Cited
2002
PURPOSE We discovered that breast cancer resistance protein (BCRP), a recently identified adenosine triphosphate-binding cassette… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE To compare the efficacy and safety of pegylated liposomal doxorubicin (PLD) and topotecan in patients with epithelial… Expand
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Highly Cited
2001
Highly Cited
2001
  • Z. Peng, X. Peng
  • Journal of the American Chemical Society
  • 2001
  • Corpus ID: 10545306
High-quality colloidal semiconductor nanocrystals are nanometer-sized, single crystalline fragments of the corresponding bulk… Expand
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Highly Cited
2001
Highly Cited
2001
Highly monodisperse CdSe nanocrystals were prepared in a three-component hexadecylamine−trioctylphosphine oxide−trioctylphosphine… Expand
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Highly Cited
2001
Highly Cited
2001
The synthesis and study of so-called “nanoparticles”, particles with diameters in the range of 1−20 nm, has become a major… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND AND METHODS Breast cancer resistance protein (BCRP/MXR/ABCP) is a multidrug-resistance protein that is a member of the… Expand
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Highly Cited
1997
Highly Cited
1997
PURPOSE Topotecan and paclitaxel were evaluated in a randomized, multicenter study of patients with advanced epithelial ovarian… Expand
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