• Publications
  • Influence
Aminopeptidase N (CD13) as a target for cancer chemotherapy
The enzyme aminopeptidase N (APN, also known as CD13) is a Zn2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal neutral amino acid.Expand
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The fluorometric microculture cytotoxicity assay
The fluorometric microculture cytotoxicity assay (FMCA) is a nonclonogenic microplate-based cell viability assay used for measurement of the cytotoxic and/or cytostatic effect of different compoundsExpand
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Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study
Patients with peritoneal or local metastases from colorectal cancer have a poor prognosis. However, aggressive treatments by debulking surgery and infusional intraperitoneal (i.p.) chemotherapy haveExpand
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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells. Such cellsExpand
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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, weExpand
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A systematic overview of chemotherapy effects in colorectal cancer.
A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for the evaluation of theExpand
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Pharmacokinetic models for the saturable distribution of paclitaxel.
Paclitaxel pharmacokinetics are nonlinear with saturable metabolism and saturable distribution to the tissues. The saturable distribution has in previous pharmacokinetic modeling been described as aExpand
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Inhibition of proteasome activity, nuclear factor‐KB translocation and cell survival by the antialcoholism drug disulfiram
The proteasome pathway is an important target for anticancer drug development. Here, we identify the antialcoholism drug disulfiram and its analogue pyrrolidine dithiocarbamate (PDTC) as inhibitorsExpand
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Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients.
The aim of this study was to validate and further develop a mechanism-based population pharmacokinetic model for paclitaxel (Taxol; Bristol-Myers Squibb Co, Princeton, NJ, USA) based on the knowledgeExpand
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What is cancer chemotherapy?
  • P. Nygren
  • Medicine
  • Acta oncologica
  • 1 January 2001
The importance of chemotherapy for cure of cancer is increasing, especially with its use as adjuvans to local therapy. Furthermore, in advanced disease, when the tumour has disseminated from itsExpand
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