• Publications
  • Influence
Aminopeptidase N (CD13) as a target for cancer chemotherapy
The prevalence and possible function of APN in malignant diseases, mainly solid tumors, as well as its “drugability” evaluated in preclinical in vivo models are discussed, and a brief overview of current clinical trials focused on APN is provided.
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
The small molecule VLX600 is identified as a drug that is preferentially active against quiescent cells in colon cancer 3-D microtissues and displays tumour growth inhibition in vivo, suggesting that tumours in metabolically compromised microenvironments have a limited ability to respond to decreased mitochondrial function.
Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study
The results indicate that patients with peritoneal metastases and/or locally advanced cancers but without distant metastases may benefit from cytoreductive surgery combined with i.p. chemotherapy.
The fluorometric microculture cytotoxicity assay
The fluorometric microculture cytotoxicity assay (FMCA) is a nonclonogenic microplate-based cell viability assay used for measurement of the cytotoxic and/or cytostatic effect of different compounds
Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA)
The results suggest that the FMCA may be a simple and rapid method for in vivo‐representative determinations of chemotherapeutic drug resistance in tumor cells obtained from patients with leukemia.
A systematic overview of chemotherapy effects in colorectal cancer.
A meta-analysis of nine randomised trials revealed a small but statistically significant benefit in five-year survival and a reduction in the risk of death for the patients receiving immediate postoperative portal vein infusion compared with controls, supported by similarly limited effects in two recently reported very large European multicentre trials.
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
It is reported that the FDA-approved anthelmintic drug nitazoxanide could be a potential candidate for advancement into cancer clinical trials and it is shown that all five compounds inhibit mitochondrial respiration, suggesting that cancer cells in low glucose concentrations depend on oxidative phosphorylation rather than solely glycolysis.
Pharmacokinetic models for the saturable distribution of paclitaxel.
It was found that the observed data could be equally well described by saturable tissue binding as well as by capacity-limited tissue transport, suggesting a possible connection between the binding sites involved in the pharmacokinetics and the mechanism responsible for the toxicity.