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Aminopeptidase N (CD13) as a target for cancer chemotherapy
The enzyme aminopeptidase N (APN, also known as CD13) is a Zn2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal neutral amino acid.… Expand
The fluorometric microculture cytotoxicity assay
The fluorometric microculture cytotoxicity assay (FMCA) is a nonclonogenic microplate-based cell viability assay used for measurement of the cytotoxic and/or cytostatic effect of different compounds… Expand
Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study
Patients with peritoneal or local metastases from colorectal cancer have a poor prognosis. However, aggressive treatments by debulking surgery and infusional intraperitoneal (i.p.) chemotherapy have… Expand
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells. Such cells… Expand
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, we… Expand
A systematic overview of chemotherapy effects in colorectal cancer.
A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for the evaluation of the… Expand
Pharmacokinetic models for the saturable distribution of paclitaxel.
- M. Karlsson, V. Molnár, A. Freijs, P. Nygren, J. Bergh, R. Larsson
- Chemistry, Medicine
- Drug metabolism and disposition: the biological…
- 1 October 1999
Paclitaxel pharmacokinetics are nonlinear with saturable metabolism and saturable distribution to the tissues. The saturable distribution has in previous pharmacokinetic modeling been described as a… Expand
Inhibition of proteasome activity, nuclear factor‐KB translocation and cell survival by the antialcoholism drug disulfiram
- H. Lövborg, F. Öberg, L. Rickardson, J. Gullbo, P. Nygren, R. Larsson
- Biology, Medicine
- International journal of cancer
- 15 March 2006
The proteasome pathway is an important target for anticancer drug development. Here, we identify the antialcoholism drug disulfiram and its analogue pyrrolidine dithiocarbamate (PDTC) as inhibitors… Expand
Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients.
The aim of this study was to validate and further develop a mechanism-based population pharmacokinetic model for paclitaxel (Taxol; Bristol-Myers Squibb Co, Princeton, NJ, USA) based on the knowledge… Expand