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Topotecan (TPT) is in clinical use as an antitumor agent, hycamtin™. Because of this, it requires both biologically and… Expand The objective of this study was to study the efficacy and adverse effects of hycamtin for small-cell lung cancer treatment… Expand OBJECTIVE
To discuss the therapeutic effect and toxicity of second line Hycamtin for lung cancer patients.
Ten of these… Expand Objective To examine the effect of Hycamtin on two kinds of endometrial carcinoma cell lines, Ishikawa 3H12 and HEC 1A. Methods… Expand Abstract. O'Toole SA, Sheppard BL, McGuinness E, Gleeson NC, Bonnar J. Serous papillary adenocarcinomas of the ovary display… Expand BACKGROUND
Since no effective therapeutic approach is yet known for metastatic renal cell carcinoma (RCC), we analyzed the… Expand Prolonged exposure to topotecan in in vitro and in vivo experiments has yielded the highest antitumor efficacy. An oral… Expand Purpose: We have previously reported that DX-8951f, a water-soluble and nonprodrug camptothecin (CPT) derivative, exhibits both… Expand Hycamtin is a camptothecin anticancer analogue containing a dimethylaminomethyl substituent at position 9 and a hydroxy… Expand Publisher Summary There was a slight increase in the number of new chemical entities (NCEs) introduced in the world market in the… Expand