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Differential subcellular localization of functionally divergent survivin splice variants
TLDR
Data is provided on a differential subcellular localization of functionally divergent survivin variants, suggesting that survivin isoforms may perform different functions in distinct sub cellular compartments and distinct phases of the cell cycle. Expand
Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.
TLDR
A complex regulatory balance between the different isoforms of survivin might determine the response to proapoptotic stimuli, not only in human RCCs but also in fetal tissues and other types of cancer. Expand
Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia.
TLDR
Overexpression of survivin in BCP-ALL identifies patients with a high risk of early relapse and is a significant prognostic marker for 3 year relapse free, event-free and overall survival, independent of the established prognostic factors in ALL. Expand
Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas
TLDR
In vivo expression of functionally different survivin variants are demonstrated for the first time and a role of these survivin splice variants in the progression and clinical behavior of human RCCs is suggested. Expand
Survivin splice variants regulate the balance between proliferation and cell death
TLDR
It is shown that the diverse functional roles of survivin can be explained, in part, by its heterodimerization with survivin splice variants in tumor cells, which is likely to have a significant impact in the design of biologic agents for clinical therapy. Expand
Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas
TLDR
The investigation demonstrates that the delicate balance between XIAP and Smac/DIABLO expression is gradually disturbed during progression of RCCs, resulting in a relative increase of antiapoptotic XIAP over proap Optotic Smac or DIABLo, thereby probably contributing to the marked apoptosis resistance of R CC. Expand
Resistance to CD95 (APO-1/Fas)-mediated apoptosis in human renal cell carcinomas: an important factor for evasion from negative growth control.
TLDR
Resistance rather than responsiveness to CD95-mediated apoptosis is a key feature of human RCC, and this resistance might facilitate evasion from negative growth control and contribute to the failure of cytotoxic drugs in the treatment ofhuman RCC. Expand
Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage
TLDR
It is demonstrated that all RCC cell lines coexpress TRAIL and the death-inducing receptors, TRAIL-R1 and TRAil-R2, and deficient activation of caspase-9 might contribute to the clinically known resistance of human RCC against IR and also argues against an effective combination therapy with TRAil and IR in this tumour type. Expand
Caspase-8 and its inhibitors in RCCs in vivo: the prominent role of ARC
TLDR
It is revealed that ARC is the only caspase-8 inhibiting regulator being constantly overexpressed in RCCs and the balance between antiapoptotic ARC and proapoptosis casp enzyme-8 is theonly one to be disturbed during carcinogenesis and tumour progression of R CCs. Expand
Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression
TLDR
This study demonstrates for the first time the expression of alternative splice variants in gastric carcinomas and provides a first clue to a role of survivin-2B in tumour progression. Expand
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