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Topotecan Hydrochloride

Known as: Hydrochloride, Topotecan, Oral Topotecan Hydrochloride, (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione Monohydrochloride 
The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVE The mTOR inhibitor, temsirolimus, has clinical activity in the treatment of gynecologic malignancies, particularly… Expand
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Highly Cited
2004
Highly Cited
2004
We have shown previously that the camptothecin analogue topotecan (TPT), a topoisomerase I (Top 1) poison, inhibits hypoxia… Expand
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Highly Cited
2000
Highly Cited
2000
Topotecan was encapsulated in sphingomyelin/cholesterol liposomes using an ionophore-generated proton gradient. After i.v… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Topotecan is a topoisomerase I inhibitor with activity against xenografts of childhood solid tumors and established… Expand
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Highly Cited
1998
Highly Cited
1998
Topotecan undergoes both renal and hepatic elimination, with topotecan urinary recovery ranging from 60 to 70%. We evaluated the… Expand
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Review
1996
Review
1996
SummaryTopotecan (Hycamtin®), a semisynthetic water-soluble derivative of camptothecin, is a potent inhibitor of DNA… Expand
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Cisplatin-based induction chemotherapy may achieve a complete response (i.e., no sign of tumor following treatment) in… Expand
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Camptothecins belong to a group of anticancer agents with a unique mechanism of action: poisoning of eukaryotic DNA… Expand
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Highly Cited
1994
Highly Cited
1994
PURPOSE To determine the feasibility of escalating the hydrophilic topoisomerase I (topo I)-inhibitor topotecan (TPT) above… Expand
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Highly Cited
1993
Highly Cited
1993
The cytotoxic alkaloid camptothecin (CPT) and several of its analogues, including the clinically relevant topotecan (TPT… Expand
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