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Thrombomodulin Alfa

Known as: 1-498-Thrombomodulin (Human Clone TMP26/TMJ1 Protein Moiety Reduced), Beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-,ethyl ester, methanesulfonate, Thrombomodulin (human 498-amino acid fragment) 
A recombinant, soluble form of the human protein thrombomodulin, with potential anticoagulant activity. Upon administration, thrombomodulin binds to… 
National Institutes of Health

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Papers overview

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2013
2013
Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the… 
Highly Cited
2011
Highly Cited
2011
THROMBOMODULIN ALFA IN THE TREATMENT OF INFECTIOUS PATIENTS COMPLICATED BY DISSEMINATED INTRAVASCULAR COAGULATION: SUBANALYSIS FROM THE PHASE 3 TRIAL
To investigate treatment effects of thrombomodulin alfa (TM-&agr;) in patients with disseminated intravascular coagulation (DIC… 
Highly Cited
2009
Highly Cited
2009
Spartathlon, a 246 kilometer foot race: effects of acute inflammation induced by prolonged exercise on circulating progenitor reparative cells.
2008
2008
Effluent levels of thrombomodulin predict early graft function in clinical liver transplantation.
Thrombomodulin is a surface protein on vascular endothelial cells that serves as a binding site for thrombin and plays an… 
Highly Cited
2007
Highly Cited
2007
Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin.
Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to… 
1998
1998
Anticoagulant effects of 1alpha,25-dihydroxyvitamin D3 on human myelogenous leukemia cells and monocytes.
The hormonally active form of vitamin D is 1alpha, 25-dihydroxyvitamin D3 [1,25(OH)2D3], which is a principal regulator of… 
1997
1997
Anticoagulant effects of synthetic retinoids mediated via different receptors on human leukemia and umbilical vein endothelial cells.
We recently found that retinoic acids (RAs) exert anticoagulant effects by upregulating thrombomodulin (TM) and downregulating… 
1995
1995
The diagnostic value of thrombomodulin immunolocalization in serous effusions.
OBJECTIVE To test the value of an antithrombomodulin monoclonal antibody as a diagnostic tool in detecting mesothelial cells and… 
Highly Cited
1992
Highly Cited
1992
Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor.
Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) shift the hemostatic balance of endothelial cell surfaces… 
Highly Cited
1992
Highly Cited
1992
Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor
Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) shift the hemostatic balance of endothelial cell surfaces… 
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