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Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus : Lack of Correlation With Thrombomodulin Suggests Involvement of Different
2249, and Ro44-4753, respectively. These synthetic retinoids were kindly provided by F. Hoffman-La Roche, Ltd (Basel, Switzerland). Our experiments also showed that the incubation of NB4 cells withExpand
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
TLDR
It is demonstrated that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E, and indicates that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpOR. Expand
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
TLDR
It is demonstrated that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E, and indicates that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpOR. Expand
Overexpression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma by bone marrow cells from patients with myelodysplastic syndromes.
TLDR
Results suggested that disruption of hematopoiesis in MDS might be caused by enhanced production of inhibitory regulatory cytokines especially TNF-alpha and occasionally IFN-gamma by bone marrow macrophages. Expand
IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A
TLDR
It is suggested that IQGAP1 may be one of the target genes in the 15q26 amplicon correlated with a malignant phenotype of gastric cancer cells, such as diffuse and invasive characteristics, through the disruption of E-cadherin-mediated cell-cell adhesion. Expand
Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia
TLDR
The results suggest that the fas–fasl system plays an important role in inducing apoptosis in the bone marrow of patients with myelodysplastic syndromes and works in an autocrine and/or paracrine (hematopoietic cell–stromal cell interaction) manner. Expand
Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes.
TLDR
TNF- alpha-induced apoptosis may play a role in ineffective hematopoiesis in "early stage MDS" bone marrow, although the regulatory mechanisms for TNF-alpha-induced signaling would be complicated and not be simply explained only by these pathways. Expand
Pseudoinvasion of the colorectal polypoid tumors: Serial section study of problematic cases
Ten cases of endoscopically removed colorectal polypoid tumors exhibiting lobular growth patterns in the submucosa without prominent desmoplastic changes in the interstitium were investigated usingExpand
p53 expression in myeloid cells of myelodysplastic syndromes. Association with evolution of overt leukemia.
TLDR
The results suggest that p53 mutations that occur in the myeloid cells in MDS may confer a growth advantage to these cells resulting in the progression to overt leukemia. Expand
Identification of negative regulatory regions within the first exon and intron of the BCL6 gene
TLDR
Two regions in the BCL6 gene are identified, ES and IS, which are located within the first exon between nucleotides +472 and +543 and both had a silencer activity. Expand
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