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dabigatran etexilate mesylate

Known as: Beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-,ethyl ester, methanesulfonate, Etexilate Mesylate, Dabigatran, Mesylate, Dabigatran Etexilate 
An orally available mesylate salt form of the etexilate prodrug of dabigatran, a benzimidazole and direct thrombin inhibitor with anticoagulant… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (1)

Pradaxa
Thrombomodulin Alfadabigatran etexilate 150 MG Oral Capsule [Pradaxa]

Broader (2)

dabigatrandabigatran etexilate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Appropriate Apixaban Dosing: Prescribers Take Note.
Appropriate Apixaban Dosing: Prescribers Take Note Jeffrey Weitz;John Eikelboom; JAMA Cardiology 
Highly Cited
2015
Highly Cited
2015
Risk of bleeding with dabigatran in atrial fibrillation.
IMPORTANCE It remains unclear whether dabigatran etexilate mesylate is associated with higher risk of bleeding than warfarin… 
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2015
2015
Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis
Cancer is often associated with an increased risk of thrombotic events which are exacerbated by treatment with chemotherapeutics… 
Highly Cited
2014
Highly Cited
2014
Transfer of Dabigatran and Dabigatran Etexilate Mesylate Across the Dually Perfused Human Placenta
OBJECTIVE: To assess the transplacental pharmacokinetics at term of the oral thrombin inhibitor, dabigatran, and its prodrug… 
Highly Cited
2014
Highly Cited
2014
Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model
IntroductionNew oral anticoagulants are effective alternatives to warfarin. However, no specific reversal agents are available… 
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Review
2014
Review
2014
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine esterases responsible for the hydrolysis of… 
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Review
2013
Review
2013
New oral anticoagulants and the risk of intracranial hemorrhage: traditional and Bayesian meta-analysis and mixed treatment comparison of randomized trials of new oral anticoagulants in atrial…
IMPORTANCE Randomized studies have shown a decreased risk of intracranial hemorrhage (ICH) with use of novel oral anticoagulants… 
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2013
2013
Usefulness of Dabigatran Etexilate as Periprocedural Anticoagulation Therapy for Atrial Fibrillation Ablation
BackgroundThe usefulness of dabigatran etexilate for the prevention of stroke in patients with atrial fibrillation (AF) has been… 
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2013
2013
Something new under the sun? The Mediterranean diet and cardiovascular health.
  • S. W. Tracy
  • The New England journal of medicine
  • 2013
  • Corpus ID: 34159054
The history of dietary guidelines for heart health — a project begun in the 1950s when the United States felt threatened by a… 
2012
2012
Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate…
AbstractDabigatran etexilate (DABE) is an oral prodrug that is rapidly converted by esterases to dabigatran (DAB), a direct… 
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