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Thrombomodulin is present in human plasma and urine.
TLDR
It is reported that plasma and urine of normal subjects contains a modified form of thrombomodulin that is soluble, and the soluble form is smaller than the cellular form, presumably because of a lack of the membrane-binding domain.
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Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells.
TLDR
The release of TM antigen was not influenced by addition of various concentrations of monensin, which inhibits intracellular transport of secretory proteins, though the secretion of plasminogen activator inhibitor-1 from the cells was inhibited.
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Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes
TLDR
The results suggest that the onset of cytotoxicity caused by designer drugs such as MBDB and MDMA is linked to mitochondrial failure dependent upon the induction of the MPT accompanied by mitochondrial depolarization and depletion of ATP through uncoupling of oxidative phosphorylation in rat hepatocytes.
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Verotoxin-1 induces tissue factor expression in human umbilical vein endothelial cells through activation of NF-kappaB/Rel and AP-1.
TLDR
The present work suggests that both the NF-kappaB/Rel and AP-1 activated in endothelial cells by stimulation with VT-1 binds to the TF- kappaB and proximal AP- 1 binding sites, respectively, of the TF promoter.
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Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction
TLDR
Results indicate that mitochondria are target organelles for fullerenols, which elicit cytotoxicity through mitochondrial failure related to the induction of the MPT, mitochondrial depolarization, and inhibition of ATP synthesis in the early stage and subsequently oxidation of GSH and protein thiols, and lipid peroxidation through oxidative stress at a later stage.
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Establishment of enzyme immunoassay of human thrombomodulin in plasma and urine using monoclonal antibodies.
TLDR
Enzyme immunoassay, EIA, for human TM was developed using mouse monoclonal antibodies against human placental TM to measure almost all of 6 and 7 TM subspecies in plasma and urine, respectively, except 1 subspecies, 31 kDa TM.
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Biotransformation and cytotoxicity of a brominated flame retardant, tetrabromobisphenol A, and its analogues in rat hepatocytes
TLDR
Mitochondria are target organelles for TBBPA, which elicits cytotoxicity through mitochondrial dysfunction related to oxidative phosphorylation at an early stage and subsequently lipid peroxidation at a later stage, and the toxicity of T BBPA and TCBPA is greater than that of BPA, suggesting the participation of halogen atoms such as bromine and chlorine in the toxicity.
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Elevation of Plasma Thrombomodulin Level in Diabetic Patients With Early Diabetic Nephropathy
TLDR
Fasting plasma TM concentrations in 67 diabetic patients with different degrees of albuminuria are suggested to suggest that an increased influx of TM to the plasma may be caused by generalized endothelial damage in patients with early diabetic nephropathy.
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Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells.
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Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes.
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