FAQ

Thioinosine

Known as: 6-MP riboside, Thioinosine [Chemical/Ingredient], Ribosyl-6-mercaptopurine 
A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de… (More)

Topic mentions per year

Topic mentions per year

1956-2017
02419562016

Related topics

Related topics

17 relations

Narrower (8)

2'-deoxy-6-thioinosine2-fluoro-4-nitrobenzyl mercaptopurine riboside4-nitrobenzylthioinosine5'-isobutylthioinosine
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Broader (1)

Immunosuppressive Agents
In Bloodadministration & dosageagonistsantagonists & inhibitors
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Thioinosine
agonists
Immunosuppressive Agents
chemical synthesis
4-nitrobenzylthioinosine
standards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease.
BACKGROUND Adverse events leading to discontinuation or dose reduction of thiopurine therapy occur in 9-28% of patients with… (More)
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Highly Cited
2002
Highly Cited
2002
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.
Mercaptopurines have been used as anticancer agents for more than 40 years, and most acute lymphoblastic leukemias are treated… (More)
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1999
1999
Assay of 6-mercaptopurine and its metabolites in patient plasma by high-performance liquid chromatography with diode-array detection.
A reversed-phase high-performance liquid chromatography (HPLC) method was developed to determine 6-mercaptopurine (MP) and seven… (More)
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1996
1996
Dose-response relationship of teratogenicity and prenatal-toxic risk estimation of 6-mercaptopurine riboside in mice.
6-Mercaptopurine riboside (6-MPr) is used as a cytostatic chemotherapeutic. The teratogenic potential in rodents has been well… (More)
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1990
1990
Synthesis and in vivo antitumor activity of 2-amino-9H-purine-6-sulfenamide, -sulfinamide, and -sulfonamide and related purine ribonucleosides.
A number of 6-sulfenamide, 6-sulfinamide, and 6-sulfonamide derivatives of 2-aminopurine and certain related purine… (More)
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1984
1984
Identification of 6-mercaptopurine riboside in patients receiving 6-mercaptopurine as a prolonged intravenous infusion.
 
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1982
1982
Purine catabolism in plants : purification and some properties of inosine nucleosidase from yellow lupin (lupinus luteus L.) seeds.
Inosine nucleosidase (EC 3.2.2.2), the enzyme which hydrolyzes inosine to hypoxanthine and ribose, has been partially purified… (More)
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1981
1981
Different sites of adenosine formation in the heart.
In an attempt to further define the site of myocardial adenosine formation, isolated guinea pig hearts were perfused with potent… (More)
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1969
1969
Stimulatory effects of inosine and deoxyinosine on the incorporation of uracil-2-14-C, 5-fluorouracil-2-14-C, and 5-bromouracil-2-14-C into nucleic acids by Ehrlich ascites tumor cells in vitro.
been demonstrated. The transfer of pentose from purine nude osides to pyrimidine bases is the subject of this communica tion… (More)
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1966
1966
Conversion of 6-mercaptopurine and 6-mercaptopurine ribonucleoside to 6-methylmercaptopurine ribonucleotide in human epidermoid carcinoma no. 2. cells in culture.
 
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