Thiazides

Known as: Thiazides [Chemical/Ingredient], thiazide 
Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM… (More)
National Institutes of Health

Related topics

Related topics

19 relations
BendroflumethiazideChlorothiazideChlorothiazide 500 MG InjectionChlorothiazide sodium
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Broader (3)

BenzothiadiazinesDiureticsThiadiazines

Narrower (1)

Diazoxide

Papers overview

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Highly Cited
2012
Highly Cited
2012
2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).
Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and… (More)
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Review
2010
Review
2010
Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics.
Thiazide and thiazide-like diuretics are among the most commonly used antihypertensives and have been available for over 50 years… (More)
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Highly Cited
2005
Highly Cited
2005
Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.
Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl- cotransporter (NCC), and mutations in NCC result in… (More)
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Highly Cited
2005
Highly Cited
2005
Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian…
BACKGROUND The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been… (More)
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Highly Cited
2003
Highly Cited
2003
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on… (More)
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Highly Cited
2003
Highly Cited
2003
Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials.
OBJECTIVE To determine the average reduction in blood pressure, prevalence of adverse effects, and reduction in risk of stroke… (More)
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Highly Cited
2003
Highly Cited
2003
WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
Pseudohypoaldosteronism type II (PHAII) is an autosomal dominant disorder of hyperkalemia and hypertension. Mutations in two… (More)
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Highly Cited
2003
Highly Cited
2003
A strategy to reduce cardiovascular disease by more than 80%.
OBJECTIVES To determine the combination of drugs and vitamins, and their doses, for use in a single daily pill to achieve a large… (More)
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Highly Cited
1998
Highly Cited
1998
The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein.
Although the collecting duct is regarded as the primary site at which mineralocorticoids regulate renal sodium transport in the… (More)
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Highly Cited
1996
Highly Cited
1996
Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter
Maintenance of fluid and electrolyte homeostasis is critical for normal neuromuscular function. Bartter's syndrome is an… (More)
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