Chlorothiazide

Known as: Chlorothiazid, 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide, Chlorthiazide 
A short-acting, benzothiadiazinesulfonamide derivative and prototypical thiazide diuretic. Chlorothiazide is excreted unchanged by the kidneys.
National Institutes of Health

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1956-2017
05010015019562016

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1992
1992
Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on… (More)
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1991
1991
Video microscopy was used to study the regulation of cell volume in isolated rabbit ventricular myocytes. Myocytes rapidly (less… (More)
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Highly Cited
1989
Highly Cited
1989
The mechanism of the diuretic braking phenomenon was studied in nine male hypertensive patients by assessing the diurnal pattern… (More)
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Highly Cited
1978
Highly Cited
1978
Calcium and sodium transport were studied in the distal convoluted tubule of the rat by micropuncture and microperfusion… (More)
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1975
1975
The saluretic effect of the thiazide diuretics has been attributed to inhibition of sodium reabsorption in the distal nephron of… (More)
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1974
1974
Clearance experiments were performed in female mongrel dogs, either intact or thyro-parathy-roidectomized (T-PTX), under… (More)
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1960
1960
0 NLY two studies have been published that detail the changes in cardiac output after chlorothiazide.*p* Other report@ have… (More)
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1959
1959
The importance of plasma and extracellular fluid volumes in the mechanism of the antihypertensive effect of chlorothiazide is… (More)
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1959
1959
LARAGH and his co-workers1 have demonstrated that chlorothiazid administered to normal subjects in the midst of a sustained water… (More)
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1958
1958
Chlorothiazide was synthesized by Novello and Sprague’ and found to be a potent, orally effective diuretic and saluretic agent by… (More)
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