Skip to search formSkip to main contentSkip to account menu

Chlorothiazide

Known as: Chlorothiazid, 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide, Chlorthiazide 
A short-acting, benzothiadiazinesulfonamide derivative and prototypical thiazide diuretic. Chlorothiazide is excreted unchanged by the kidneys.
National Institutes of Health

Related topics

Related topics

28 relations

Broader (2)

Antihypertensive AgentsDiuretics
AnuriaChlorothiazide 500 MG InjectionChlorothiazide 500 MG Injection [Diuril]Chlorothiazide:PrThr:Pt:Ser/Plas:Ord

Narrower (3)

Chlorothiazide sodiumDiurilUroflux

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Determination of 8 Diuretics and Probenecid in Human Urine by Gas Chromatography-Mass Spectrometry: Confirmation Procedure
A fast and sensitive method for determination of 8 diuretics (acetazolamide, bendroflumethiazide, bumetanide, chlorthalidone… 
1979
1979
Bioavailability of chlorothiazide tablets in humans.
A urinary excretion bioavailability study was conducted in 12 healthy male subjects to evaluate three 250-mg and three 500-mg… 
1978
1978
The renin-aldosterone system and thiazide-induced depletion of total body potassium in essential hypertension.
15 patients who had benign, uncomplicated essential hypertension, were treated with chlorthiazide (500 mg twice a day) with or… 
1976
1976
Effect of chlorothiazide on the pharmacokinetics of lithium in plasma and erythrocytes.
The effect of chlorothiazide on the pharmacokinetics of lithium in both plasma and RBCs was studied in normal adult males. This… 
1974
1974
Liquid chromatography in pharmaceutical analysis II: determination of a reserpine-chlorothiazide mixture.
Abstract Operating conditions are described for the qualitative and quantitative analysis of a reserpine–chlorothiazide mixture… 
1964
1964
THE EVALUATION OF ANTIHYPERTENSIVE THERAPY COOPERATIVE CLINICAL TRIAL METHOD. I. DOUBLE-BLIND CONTROL COMPARISON OF CHLOROTHIAZIDE, RAUWOLFIA SERPENTINA, AND HYDRALAZINE.
Excerpt The need for adequate clinical trial of therapeutic agents is particularly evident in the field of antihypertensive drugs… 
1962
1962
Effect of Chlorothiazide on Response of Renal Vascular Bed to Vasoactive Substances
In the anesthetized dog, administration of an isosmotic solution of chlorothiazide into the renal artery failed to affect renal… 
1962
1962
Effect of chlorothiazide upon aldosterone excretion and sodium and potassium balance in essential hypertension.
l’hrsa investigations were designed to study the early effects of chlorothia&e On aldostwone excretion in patients w<th essential… 
1960
1960
Hemodynamic and Hypotensive Effects of Long-term Therapy with Chlorothiazide
Long-term treatment of hypertension with chlorothiazide alone produces mioderate reduction in blood pressure in 66 per cent of… 
Highly Cited
1957
Highly Cited
1957
Clinical and Laboratory Observations on Chlorothiazide (Diuril) An Orally Effective Nonmercurial Diuretic Agent
Chlorothiazide* is a compound whose properties make it valuable in cases where it is desirable to increase the elimination of…