Diazoxide

Known as: Diazoxide [Chemical/Ingredient], 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide 
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Protection by ischemic preconditioning is lost in cardiomyocytes and hearts of heterozygous connexin 43 deficient (Cx43+/-) mice… (More)
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Highly Cited
2005
Highly Cited
2005
Reactive oxygen species (ROS) are key mediators in signal transduction of angiotensin II (Ang II). However, roles of vascular… (More)
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Highly Cited
2003
Highly Cited
2003
A mitochondrial sulphonylurea-sensitive, ATP-sensitive K+ channel (mitoKATP) that is selectively inhibited by 5-hydroxydecanoate… (More)
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Highly Cited
2002
Highly Cited
2002
Diazoxide and 5-hydroxydecanoate (5-HD; C10:0) are reputed to target specifically mitochondrial ATP-sensitive K(+) (K(ATP… (More)
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Highly Cited
2002
Highly Cited
2002
Studies with different ATP-sensitive potassium (K(ATP)) channel openers and blockers have implicated opening of mitochondrial K… (More)
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Highly Cited
2001
Highly Cited
2001
Diazoxide, a selective opener of the mitochondrial ATP-sensitive potassium channel, has been shown to elicit tolerance to… (More)
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Review
2000
Review
2000
Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-cells. The triggering pathway is… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The… (More)
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Highly Cited
1997
Highly Cited
1997
Previous studies showed a poor correlation between sarcolemmal K+ currents and cardioprotection for ATP-sensitive K+ channel… (More)
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Highly Cited
1997
Highly Cited
1997
KATP channels were reconstituted in COSm6 cells by coexpression of the sulfonylurea receptor SUR1 and the inward rectifier… (More)
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