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Diazoxide

Known as: Diazoxide [Chemical/Ingredient], 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide 
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in… 
National Institutes of Health

Related topics

Related topics

20 relations

Broader (3)

Antihypertensive AgentsThiazidesVasodilator Agents
Decreased Blood Pressure [PE]Diazoxide 50 MG/ML Oral Suspension [Proglycem]Diazoxide:MCnc:Pt:Ser/Plas:QnDrug Allergy

Narrower (3)

HyperstatProglycemSRG-95213

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Differential K(ATP) channel pharmacology in intact mouse heart.
Highly Cited
2004
Highly Cited
2004
A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell.
Highly Cited
2002
Highly Cited
2002
Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.
Highly Cited
2001
Highly Cited
2001
Mitochondrial K(ATP) channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation.
Highly Cited
1993
Highly Cited
1993
Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion.
Highly Cited
1990
Highly Cited
1990
Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels.
Highly Cited
1989
Highly Cited
1989
Dual effects of diazoxide on ATP‐K+ currents recorded from an insulin‐secreting cell line
1 The effects of diazoxide on ATP‐K+ channel currents, recorded from the insulin‐secreting cell line, CRI‐G1, were studied using… 
Highly Cited
1987
Highly Cited
1987
Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
Highly Cited
1982
Highly Cited
1982
Diazoxide and D600 Inhibition of Insulin Release: Distinct Mechanisms Explain the Specificity for Different Stimuli
The mechanisms by which diazoxide and D600 affect insulin release have been compared in experiments using isolated rat islets… 
Highly Cited
1968
Highly Cited
1968
Insulin-secreting bronchial carcinoid tumor with widespread metastases.
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