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Diazoxide

Known as: Diazoxide [Chemical/Ingredient], 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide 
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in… 
National Institutes of Health

Related topics

Related topics

20 relations

Broader (3)

Antihypertensive AgentsThiazidesVasodilator Agents
Decreased Blood Pressure [PE]Diazoxide 50 MG/ML Oral Suspension [Proglycem]Diazoxide:MCnc:Pt:Ser/Plas:QnDrug Allergy

Narrower (3)

HyperstatProglycemSRG-95213

Papers overview

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Highly Cited
1977
Highly Cited
1977
Neonatal and infantile hypoglycemia due to insulin excess: new aspects of diagnosis and surgical management.
Persistent hypoglycemia in the neonate and young infant usually results from inappropriate, excessive secretion of insulin, or a… 
1977
1977
Dose-Response Relation of Diazoxide in Children with Hypertension
Diazoxide was administered to sixteen pediatric patients (ages 10 months to 13 years) with secondary forms of hypertension… 
Review
1976
Review
1976
Pharmacologic modulation of inflammatory mediator release by rat mast cells.
Current knowledge of the mechanism of inflammatory mediator release from mast cells is reviewed with particular reference to the… 
1971
1971
Nonketoacidotic Hyperglycemia and Coma During Intravenous Diazoxide Therapy in Uremia
Hyperglycemic hyperosmolar nonketoacidotic coma developed in a twenty-year-old female with uremia when treated for hypertension… 
1971
1971
Insulin Secretion Studied in the Perfused Rat Pancreas: I. Effect of Tolbutamide, Leucine and Arginine; Their Interaction with Diazoxide, and Relation to Glucose
Glucose produced a diphasic pattern of insulin secretion in the perfused rat pancreas. Both phases were blocked by diazoxide… 
1971
1971
The action of diazoxide on isolated vascular smooth muscle electrophysiology and contraction.
Diazoxide inhibits spontaneous motility and contractile responses to noradrenaline, serotonin, or procaine in isolated rabbit… 
1971
1971
Insulin Secretion Studied in the Perfused Rat Pancreas: II. Effect of Glucose, Glucagon, 3'5' Adenosine Monophosphate, Theophylline, Imidazole and Phenoxybenzamine; Their Interaction with Diazoxide
This communication reports studies dealing with the action of glucagon, theophylline, cyclic adenosine monophosphate (3′5′.AMP… 
1970
1970
Studies of Insulin Secretion in the Perfused Rat Pancreas: Effect of Diazoxide and A025
Continuous glucose stimulation produces two phases of insulin secretion in the isolated perfused rat pancreas. Puromycin has no… 
Highly Cited
1969
Highly Cited
1969
The Morphological Substrate of the Inhibition of Insulin Secretion by Diazoxide* **
1. Degranulation of B-ceUs of rats infused with guinea-pig anti-insulin serum (AIS) for 3-4 hrs ean be prevented completely by… 
1967
1967
Mechanisms of action of diazoxide.
Abstract The mechanism of action of diazoxide vas investigated in dogs. Immunoreactive insulin, glucose, and free fatty acids…