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Theophylline

Known as: 1,3-dimethyl-7H-purine-2,6-dione, 1,3-dimethylxanthine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione 
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (32)

7,7'-succinylditheophylline8-phenyltheophyllineABC 99Armophylline
AnalepticsBronchitisBronchodilation [PE]CYP1A2 protein, human

Broader (3)

Enzyme InhibitorsPurinergic P1 Receptor AntagonistsVasodilator Agents

Papers overview

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Highly Cited
2009
Highly Cited
2009
Insulin Secretion During Development: Response of Isolated Pancreatic Islets of Fetal, Newborn and Adult Rats to Theophylline and Arginine*
CII/mce, R.E., R.M. EI/is: Proinsulin: Single-chain precursor of insulin. Arch.int.Med 123: 229 (1969) J)Qvoren, P.R.: The… 
1986
1986
The pulmonary disposition of theophylline and its influence on human alveolar macrophage bactericidal function.
We studied the pulmonary disposition of theophylline by performing bronchoalveolar lavage on 19 normal, nonsmoking volunteers who… 
1984
1984
In vivo effects of microinjected alkaline phosphatase and its low molecular weight substrates on the first meiotic cell division in Xenopus laevis oocytes.
Xenopus laevis oocytes were microinjected with low molecular weight phosphoesters such as 2-glycerophosphate, phosphotyrosine… 
Highly Cited
1983
Highly Cited
1983
Investigation of diurnal changes in the disposition of theophylline.
The mechanism of observed temporal variations in plasma theophylline concentrations has been investigated. Eight healthy… 
Highly Cited
1982
Highly Cited
1982
Seizure activity in animals given enprofylline and theophylline, two xanthines with partly different mechanisms of action.
Theophylline, that is a potent adenosine receptor antagonist, and enprofylline (3-propylxanthine), that seems to lack antagonism… 
1979
1979
Effect of pH on the binding of theophylline to serum proteins.
The binding of theophylline to serum protein within the pH range of 7.0 to 7.8 was determined by equilibrium dialysis using serum… 
1977
1977
Apparent theophylline half-life fluctuations during treatment of acute left ventricular failure.
The administration of theophylline in a 63-year-old man with arteriosclerotic heart disease and chronic bronchitis is discussed… 
1976
1976
Serum theophylline analysis by high-pressure liquid chromatography.
We have developed and evaluated a rapid, high-pressure liquid-chromatographic method for theophylline in serum. Only 0.2 ml of… 
1976
1976
High-pressure liquid chromatographic and spectrophotometric assays for theophylline in biological fluids.
The analysis of theophylline and other xanthine derivatives in biological fluids was examined by high-pressure liquid… 
Highly Cited
1975
Highly Cited
1975
Rapid analysis for theophylline in serum by use of high-pressure cation-exchange chromatography.
We have developed a quantitative assay for serum theophylline by high-pressure cation-exchange chromatography. As little as 0.1…