Theophylline

Known as: 1,3-dimethyl-7H-purine-2,6-dione, 1,3-dimethylxanthine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione 
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
RATIONALE Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Inhaled corticosteroids (ICS) have proved disappointing at reducing airway inflammation in COPD. However, previous… (More)
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Highly Cited
2007
Highly Cited
2007
In this study, investigation of an oral colon specific, pulsatile device to achieve time and/or site specific release of… (More)
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Highly Cited
2004
Highly Cited
2004
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease of the lungs with little or no response to… (More)
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Highly Cited
2002
Highly Cited
2002
STUDY OBJECTIVE To compare the efficacy, tolerability, and safety of therapy with formoterol and oral slow-release theophylline… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Patients with COPD often require multiple therapies to improve lung function and decrease symptoms and exacerbations… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Theophylline has been used to treat central apnea associated with Cheyne-Stokes respiration (periodic breathing). We… (More)
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Highly Cited
1995
Highly Cited
1995
Theophylline is the most widely used anti-asthma drug worldwide and is classified as a bronchodilator, although there is… (More)
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Highly Cited
1994
Highly Cited
1994
Theophylline, in addition to its bronchodilator effect, may attenuate inflammation in asthma. We did a double-blind placebo… (More)
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Highly Cited
1991
Highly Cited
1991
The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a… (More)
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