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Theophylline

Known as: 1,3-dimethyl-7H-purine-2,6-dione, 1,3-dimethylxanthine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione 
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit… 
National Institutes of Health

Related topics

Related topics

49 relations

Narrower (32)

7,7'-succinylditheophylline8-phenyltheophyllineABC 99Armophylline
AnalepticsBronchitisBronchodilation [PE]CYP1A2 protein, human

Broader (3)

Enzyme InhibitorsPurinergic P1 Receptor AntagonistsVasodilator Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1985
Highly Cited
1985
Nocturnal asthma: effect of a once per evening dose of sustained release theophylline.
In a double-blind, multiple-dose, cross-over study the therapeutic effects of an S-R theophylline preparation given once each… 
Highly Cited
1982
Highly Cited
1982
Theophylline serum concentration and therapeutic effect in severe acute bronchial obstruction: the optimal use of intravenously administered aminophylline.
In 20 patients with acute exacerbation of bronchial obstruction, the therapeutic effect of high (20 mg/L) and low (10 mg/L) serum… 
Highly Cited
1982
Highly Cited
1982
Seizure activity in animals given enprofylline and theophylline, two xanthines with partly different mechanisms of action.
Theophylline, that is a potent adenosine receptor antagonist, and enprofylline (3-propylxanthine), that seems to lack antagonism… 
Highly Cited
1980
Highly Cited
1980
Development of Insulin Release by Fetal Rat Pancreas In Vitro: Effects of Glucose, Amino Acids, and Theophylline
The dynamics of insulin release by pieces of fetal rat pancreas from 17.5 to 21.5 days of gestation was measured in an in vitro… 
Highly Cited
1979
Highly Cited
1979
Theophylline poisoning in adults.
The City of Birmingham Environmental Department analysed the paint and concluded that the solvent consisted of mixed isomers of… 
Highly Cited
1979
Highly Cited
1979
Impaired theophylline clearance in patients with cor pulmonale.
1 The relationship between serum theophylline concentration and daily dose was studied in 45 patients receiving aminophylline… 
Highly Cited
1978
Highly Cited
1978
Comparative studies of the effects of drugs on X-ray-induced G2 delay.
The mitotic cell selection technique was used to monitor the effects of various drugs, primarily inhibitors of RNA synthesis, on… 
Highly Cited
1978
Highly Cited
1978
Amphibian oocyte maturation and protein synthesis: related inhibition by cyclic AMP, theophylline, and papaverine.
Two inhibitors of cyclic AMP phosphodiesterase (3':5'-cyclic-AMP 5'-nucleotidohydrolase, EC 3.1.4.17), theophylline and… 
Highly Cited
1975
Highly Cited
1975
Rapid analysis for theophylline in serum by use of high-pressure cation-exchange chromatography.
We have developed a quantitative assay for serum theophylline by high-pressure cation-exchange chromatography. As little as 0.1… 
Highly Cited
1974
Highly Cited
1974
Rational Use of Theophylline for Bronchodilatation
A recent New England Journal of Medicine publication1 demonstrated the value of applying pharmacokinetic principles in the… 
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