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The Sequence of the Human Genome
Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated.
POTASSIUM TRANSPORT IN NEUROSPORA. I. INTRACELLULAR SODIUM AND POTASSIUM CONCENTRATIONS, AND CATION REQUIREMENTS FOR GROWTH.
Tandem Phosphorylation of Ser-911 and Thr-912 at the C Terminus of Yeast Plasma Membrane H+-ATPase Leads to Glucose-dependent Activation*
A mechanism in which the stepwise phosphorylation of two tandemly positioned residues near the C terminus mediates glucose-dependent activation of the H+-ATPase is pointed to.
Maturation of the yeast plasma membrane [H+]ATPase involves phosphorylation during intracellular transport
This study shows that the plasma membrane [H+]ATPase of Saccharomyces cerevisiae is phosphorylated on multiple Ser and Thr residues in vivo and suggests that reversible, site-specific phosphorylation serves to adjust ATPase activity in response to nutritional signals.
The proton-translocating ATPase of the fungal plasma membrane.
Expression of the yeast plasma membrane [H+]ATPase in secretory vesicles. A new strategy for directed mutagenesis.
The vesicles appear well suited for the production and characterization of mutant forms of the PMA1 [H+]ATPase and should also aid the study of other yeast membrane proteins that are essential for growth as well as heterologous proteins whose appearance in the plasma membrane may be toxic to the cell.
Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H(+)-ATPase.
The effects of vanadate on the plasma membrane ATPase of Neurospora crassa.
The results can best be accounted for in terms of a single plasma membrane ATPase which is subject to nonspecific salt effects, and are difficult to reconcile with the idea that the K+-stimulated portion of ATPase activity represents a discrete enzyme involved in K+ transport.
Effects of inhibitors on the plasma membrane and mitochondrial adenosine triphosphatases of Neurospora crassa.
Phosphorylation Region of the Yeast Plasma-membrane H+-ATPase
- N. Dewitt, C. F. Dos Santos, K. Allen, C. Slayman
- BiologyThe Journal of Biological Chemistry
- 21 August 1998
Alanine-scanning mutagenesis shows that the residues surrounding Asp-378 are critically important for ATPase maturation and transport to the cell surface, and indicates that the phosphorylation region as a whole is involved.