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Tetrahydropapaveroline

Known as: 6,7-Isoquinolinediol, 1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-, Norlaudanosoline, Norlaudansoline 
A leukomaine (animal alkaloid) formed in brain and liver from dopamine and L-dopa; it may be implicated in psychiatric problems.
National Institutes of Health

Related topics

Related topics

14 relations

Broader (3)

1,2,3,4-tetrahydroisoquinolineTetrahydroisoquinolinespapaveroline

Narrower (4)

3',4'-deoxynorlaudanosolinecarboxylic acidCSH 118UTENnorlaudanosoline-1-carboxylic acid
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine
We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes… 
Highly Cited
2003
Highly Cited
2003
Tyrosinase protects human melanocytes from ROS-generating compounds.
Highly Cited
1998
Highly Cited
1998
Antioxidants inhibit the in vitro production of inflammatory cytokines in Crohn's disease and ulcerative colitis
Modulation of cytokine secretion may be of interest in the treatment of Crohn's disease or ulcerative colitis. 
1994
1994
The formation of benzophenanthridine alkaloids
Abstract 
Highly Cited
1985
Highly Cited
1985
Benzylisoquinoline Biosynthesis by Cultivated Plant Cells and Isolated Enzymes
-Plant cell cultures rather than differentiated plants are the preferred material for studying secondary product formation and… 
Highly Cited
1983
Highly Cited
1983
Partial Purification and Properties of (S)-Norlaudanosoline Synthase from Eschscholtzia tenuifolia Cell Cultures.
A new enzyme, (S)-norlaudanosoline synthase, which catalyses the synthesis of (S)-norlaudanosoline from dopamine and 3,4… 
Highly Cited
1977
Highly Cited
1977
Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain.
Tetrahydropapaveroline (THP), a dopamine-dopaldehyde condensation product, was delivered directly into the cerebral ventricle of… 
Highly Cited
1972
Highly Cited
1972
Effects of aporphine and emetine alkaloids on central dopaminergic mechanisms in rats.
Highly Cited
1970
Highly Cited
1970
Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro.
Tetrahydropapaveroline (THP) has been found to be a quantitatively important metabolic product of dopamine-C14 in rat brainstem… 
Highly Cited
1964
Highly Cited
1964
Formation of Tetrahydropapaveroline from Dopamine in vitro
IN 1938, Holtz et al.1 reported that dopamine, which is pressor in the cat, was converted to a depressor substance after… 
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