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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
We describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin. TheExpand
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Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
Spontaneous discharge of norepinephrine-containing locus coeruleus (NE- LC) neurons was examined during the sleep-walking cycle (S-WC) in behaving rats. Single unit and multiple unit extracellularExpand
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The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations
cDNA clones of a neuronal-specific mRNA encoding a novel 25-kD synaptosomal protein, SNAP-25, that is widely, but differentially expressed by diverse neuronal subpopulations of the mammalian nervousExpand
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Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor in ethanol reinforcement and genetically determined ethanol preference. This hypothesis was tested by measuringExpand
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Nucleus locus ceruleus: new evidence of anatomical and physiological specificity.
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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous mouse models have been generated. In both AD patients and mouse models, there is increasing evidence thatExpand
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Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems.
The intensity of research on the central catecholaminergic neuron systems has continued unabated since last year's review of the dopaminergic systems (Moore & Bloom 1978). Although our originalExpand
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Modulation of early sensory processing in human auditory cortex during auditory selective attention.
Neuromagnetic fields were recorded from human subjects as they listened selectively to sequences of rapidly presented tones in one ear while ignoring tones of a different pitch in the opposite ear.Expand
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Cellular and molecular mechanisms of drug dependence.
The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediateExpand
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Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats
Self-administration of ethanol reinstated and maintained DA release at prewithdrawal levels but failed to completely restore 5-HT efflux. Expand
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