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Terfenadine

Known as: 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-, Terfenadina, alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol 
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
  • D. Roden
  • The New England journal of medicine
  • 2004
  • Corpus ID: 15251057
The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation… Expand
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Review
2003
Review
2003
In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he… Expand
Review
2001
Review
2001
  • A. Li
  • Drug discovery today
  • 2001
  • Corpus ID: 46441373
There is no doubt that ADME/Tox drug properties, absorption, distribution, metabolism, elimination and toxicity, are properties… Expand
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Highly Cited
2001
Highly Cited
2001
  • M. Malik
  • Journal of cardiovascular electrophysiology
  • 2001
  • Corpus ID: 23758847
Problems of Drug‐Prolonged QTc Assessment. Introduction: Estimation of QT interval prolongation belongs to safety assessment of… Expand
Highly Cited
1997
Highly Cited
1997
Grapefruit juice increases the oral availability of a variety of CYP3A4 substrates. It has been shown that recurrent grapefruit… Expand
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Highly Cited
1996
Highly Cited
1996
  • M Roy, R. Dumaine, A M Brown
  • Circulation
  • 1996
  • Corpus ID: 41775976
BACKGROUND Administration of the antihistamine terfenadine (Seldane) to patients may result in acquired long QT syndrome and… Expand
Highly Cited
1993
Highly Cited
1993
OBJECTIVES AND METHODS To gain insight into possible mechanisms of and predisposing factors for torsades de pointes during… Expand
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Highly Cited
1993
Highly Cited
1993
OBJECTIVE To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization… Expand
Highly Cited
1992
Highly Cited
1992
Terfenadine is a nonsedating H1‐antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole… Expand
Highly Cited
1990
Highly Cited
1990
Torsades de pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval… Expand