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Terfenadine

Known as: 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-, Terfenadina, alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol 
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic… 
National Institutes of Health

Related topics

Related topics

48 relations
200 ML Fluconazole 2 MG/ML Injection24 HR Clarithromycin 500 MG Extended Release Oral TabletCYP3A7 protein, humanCisapride

Narrower (13)

AllegraBalkis Saft SpezialFexofenadine hydrochlorideMDL 16,455A

Broader (3)

Anti-Allergic AgentsHistamine H1 AntagonistsHistamine H1 Antagonists, Non-Sedating

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Terfenadine (Seldane) is a potent and selective histamine H1 receptor antagonist in asthmatic airways.
Terfenadine (Seldane) is a new, highly potent H1 histamine receptor antagonist that in clinically effective doses is free of side… 
2006
2006
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
Highly Cited
2005
Highly Cited
2005
Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences.
Highly Cited
2005
Highly Cited
2005
Cardiovascular parameters in anaesthetized guinea pigs: a safety pharmacology screening model.
Review
2003
Review
2003
Prospects for antihistamines in the treatment of asthma.
Highly Cited
1993
Highly Cited
1993
Prevention of pollen rhinitis symptoms: comparison of fluticasone propionate aqueous nasal spray and disodium cromoglycate aqueous nasal spray
Fluticasone propionate aqueous spray, a new intranasal corticosteroid preparation, and disodium eromoglyeate 2% aqueous nasal… 
Highly Cited
1990
Highly Cited
1990
Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination.
We investigated the effects of terfenadine, a histamine H1-receptor antagonist, and flurbiprofen, a cyclooxygenase inhibitor, on… 
Highly Cited
1989
Highly Cited
1989
The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma.
Inhaled adenosine and adenosine 5'-monophosphate (AMP) cause bronchoconstriction in atopic and nonatopic asthmatics by a… 
Highly Cited
1988
Highly Cited
1988
Intranasal nedocromil sodium in the treatment of ragweed-allergic rhinitis.
Highly Cited
1984
Highly Cited
1984
Terfenadine in exercise induced asthma.
sentinel disease in patients in the United States.3 A paraneoplastic syndrome has been postulated, since direct tumour… 
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