Terfenadine

Known as: 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-, Terfenadina, alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol 
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic… (More)
National Institutes of Health

Papers overview

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Review
2004
Review
2004
Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs. The objective of this article is to… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The Brugada syndrome displays an autosomal dominant mode of transmission with low penetrance. Despite equal genetic… (More)
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Review
2000
Review
2000
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… (More)
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Review
1998
Review
1998
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… (More)
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Highly Cited
1996
Highly Cited
1996
The widely used histamine receptor antagonists terfenadine and astemizole were shown to prolong the QT interval in… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Administration of the antihistamine terfenadine (Seldane) to patients may result in acquired long QT syndrome and… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVES To establish whether the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine are affected by… (More)
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1993
1993
OBJECTIVE To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization… (More)
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Highly Cited
1992
Highly Cited
1992
Terfenadine is a nonsedating H1-antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole… (More)
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