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Terfenadine

Known as: 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-, Terfenadina, alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol 
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic… 
National Institutes of Health

Related topics

Related topics

48 relations
200 ML Fluconazole 2 MG/ML Injection24 HR Clarithromycin 500 MG Extended Release Oral TabletCYP3A7 protein, humanCisapride

Narrower (13)

AllegraBalkis Saft SpezialFexofenadine hydrochlorideMDL 16,455A

Broader (3)

Anti-Allergic AgentsHistamine H1 AntagonistsHistamine H1 Antagonists, Non-Sedating

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Brugada syndrome and ischemia-induced ST-segment elevation. Similarities and differences.
Highly Cited
2002
Highly Cited
2002
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes
This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine… 
2001
2001
Twenty-four hours of activity of cetirizine and fexofenadine in the skin.
1999
1999
In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines.
Review
1994
Review
1994
Possible interactions with terfenadine or astemizole.
Concurrent use of terfenadine or astemizole with erythromycin or ketoconazole can prolong the QT interval and produce potentially… 
Highly Cited
1993
Highly Cited
1993
Prevention of pollen rhinitis symptoms: comparison of fluticasone propionate aqueous nasal spray and disodium cromoglycate aqueous nasal spray
Fluticasone propionate aqueous spray, a new intranasal corticosteroid preparation, and disodium eromoglyeate 2% aqueous nasal… 
1993
1993
Potential Terfenadine-Fluoxetine Interaction
TO THE EDITOR: Severe anaphylactoid reactions to ciprofloxacin are very rare, developing at a rate of 1.2 per 100000… 
Highly Cited
1989
Highly Cited
1989
The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma.
Inhaled adenosine and adenosine 5'-monophosphate (AMP) cause bronchoconstriction in atopic and nonatopic asthmatics by a… 
Highly Cited
1988
Highly Cited
1988
Intranasal nedocromil sodium in the treatment of ragweed-allergic rhinitis.
1982
1982
Terfenadine, the first non-sedating antihistamine.
Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp… 
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