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The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation… Expand In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he… Expand There is no doubt that ADME/Tox drug properties, absorption, distribution, metabolism, elimination and toxicity, are properties… Expand Problems of Drug‐Prolonged QTc Assessment. Introduction: Estimation of QT interval prolongation belongs to safety assessment of… Expand Grapefruit juice increases the oral availability of a variety of CYP3A4 substrates. It has been shown that recurrent grapefruit… Expand BACKGROUND
Administration of the antihistamine terfenadine (Seldane) to patients may result in acquired long QT syndrome and… Expand OBJECTIVES AND METHODS
To gain insight into possible mechanisms of and predisposing factors for torsades de pointes during… Expand OBJECTIVE
To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization… Expand Terfenadine is a nonsedating H1‐antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole… Expand Torsades de pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval… Expand