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Fexofenadine hydrochloride

Known as: Benzeneacetic Acid, 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethyl-, Hydrochloride, Fexofenadine HCl 
The hydrochloride salt form of fexofenadine, a carboxylated metabolic derivative of terfenadine and second generation, long-lasting selective… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (1)

Allegra
Drug AllergyFexofenadine hydrochloride 180 MG Oral TabletFexofenadine hydrochloride 180 MG Oral Tablet [Allegra]Fexofenadine hydrochloride 180 MG Oral Tablet [Wal-Fex]
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Broader (1)

Terfenadine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride.
Hyaluronic acid (HA)-based microspheres containing PEG 6000 and/or sodium taurocholate (NaTC) were prepared by the spray-drying… 
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Highly Cited
2005
Highly Cited
2005
CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS
Fexofenadine hydrochloride (FEX), a second generation H1-receptor antagonist, is mainly eliminated from the liver into bile in… 
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Highly Cited
2005
Highly Cited
2005
Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).
The H1-receptor antagonist fexofenadine is a P-glycoprotein substrate [1]. However, the effects of genetic polymorphisms of the… 
Highly Cited
2004
Highly Cited
2004
A variant 2677A allele of the MDR1 gene affects fexofenadine disposition
There have been considerable disagreements regarding the influence of MDR1 (ABCB1) polymorphisms on the disposition of P… 
Highly Cited
2003
Highly Cited
2003
Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1‐week randomized, multicentre, double‐blind, placebo‐controlled, parallel‐group study
Summary Background Fexofenadine, a nonsedating, H1‐receptor selective antihistamine, exhibits consistent efficacy and safety in… 
Highly Cited
2002
Highly Cited
2002
MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.
AIMS The C3435T polymorphism in the human MDR1 gene is associated with lower intestinal P-glycoprotein expression, reduced… 
Highly Cited
2000
Highly Cited
2000
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic…
As there have been no previously published studies, this multinational, double‐blind, randomized, placebo‐controlled, parallel… 
Highly Cited
2000
Highly Cited
2000
Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria.
BACKGROUND Fexofenadine is a nonsedating antihistamine approved for treatment of seasonal allergic rhinitis. OBJECTIVE This… 
Review
1999
Review
1999
Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis.
BACKGROUND Fexofenadine HCl (Allegra, Telfast) is approved in the US for twice-daily dosing for treatment of seasonal allergic… 
Highly Cited
1999
Highly Cited
1999
A double-blind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria.
BACKGROUND Symptoms of chronic idiopathic urticaria (CIU) include relentless itching and painful wheals, which can be physically… 
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