Tangier Disease

Known as: Thesaurismoses, Cholesterol, High-Density Lipoprotein Deficiency, Tangier Type, alpha lipoprotein deficiency 
An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1950-2017
05010019502016

Papers overview

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Highly Cited
2004
Highly Cited
2004
We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular… (More)
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Highly Cited
2001
Highly Cited
2001
  • Lancet
  • 2001
BACKGROUND Atherosclerosis is the most common complication of diabetes. Correction of hyperglycaemia helps to prevent… (More)
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Highly Cited
2000
Highly Cited
2000
Mutations in the gene encoding ATP-binding cassette transporter 1 ( ABC1) have been reported in Tangier disease (TD), an… (More)
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Highly Cited
2000
Highly Cited
2000
We and others have recently identified mutations in the ABCA1 gene as the underlying cause of Tangier disease (TD) and of a… (More)
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Highly Cited
1999
Highly Cited
1999
Tangier disease (TD) is an autosomal recessive disorder of lipid metabolism. It is characterized by absence of plasma high… (More)
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Highly Cited
1999
Highly Cited
1999
Genes have a major role in the control of high-density lipoprotein (HDL) cholesterol (HDL-C) levels. Here we have identified two… (More)
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Highly Cited
1999
Highly Cited
1999
The ABC1 transporter was identified as the defect in Tangier disease by a combined strategy of gene expression microarray… (More)
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Highly Cited
1999
Highly Cited
1999
Tangier disease is characterized by low serum high density lipoproteins and a biochemical defect in the cellular efflux of lipids… (More)
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Highly Cited
1995
Highly Cited
1995
Tangier disease is a rare genetic disorder characterized by extremely low plasma levels of HDL and apo A-I, deposition of… (More)
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Highly Cited
1971
Highly Cited
1971
Risk of coronary heart disease over 14 years was examined prospectively in 2,282 men and 2,845 women according to their… (More)
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