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ABCA1 gene

Known as: CERP, ATP-BINDING CASSETTE, SUBFAMILY A, MEMBER 1, ABC TRANSPORTER 1 
This gene plays a role in intracellular cholesterol transport.
National Institutes of Health

Related topics

Related topics

11 relations
ABCA1 protein, humanATP Binding Cassette Transporter 1Cholesterol HomeostasisHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Function and regulation of ABCA1 – membrane meso‐domain organization and reorganization
The ATP‐binding cassette protein A1 (ABCA1) mediates the secretion of cellular‐free cholesterol and phospholipids to an… 
Highly Cited
2008
Highly Cited
2008
OSBP Negatively Regulates ABCA1 Protein Stability*
Oxysterol binding to liver X receptors (LXR) increases the transcription of genes involved in cholesterol efflux and disposal… 
Highly Cited
2008
Highly Cited
2008
Direct Interaction of Nuclear Liver X Receptor-β with ABCA1 Modulates Cholesterol Efflux*
Cholesterol is an essential component of eukaryotic cells; at the same time, however, hyperaccumulation of cholesterol is harmful… 
Highly Cited
2005
Highly Cited
2005
Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7 Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500092-JLR200
The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human… 
Highly Cited
2004
Highly Cited
2004
Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide Published, JLR Papers in Press, April 21, 2004. DOI 10.1194/jlr.M300358-JLR200
Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL… 
2004
2004
Alpha1-syntrophin modulates turnover of ABCA1.
ABCA1 (ATP-binding cassette transporter A1) mediates the release of cellular cholesterol and phospholipid to form high density… 
Highly Cited
2003
Highly Cited
2003
Targeting with Bovine CD154 Enhances Humoral Immune Responses Induced by a DNA Vaccine in Sheep1
CD40-CD154 interactions play an important role in regulating humoral and cell-mediated immune responses. Recently, these… 
Highly Cited
2003
Highly Cited
2003
Secretory Vesicular Transport from the Golgi Is Altered during ATP-binding Cassette Protein A1 (ABCA1)-mediated Cholesterol Efflux*
Apolipoprotein AI (apoAI)-mediated cholesterol efflux is a process by which cells export excess cellular cholesterol to apoAI to… 
Highly Cited
2002
Highly Cited
2002
The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.
Highly Cited
2001
Highly Cited
2001
Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter.
ABCA1 plays a key role in cellular cholesterol and phospholipid traffic. To explore the biochemical properties of this membrane… 
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