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ABCA1 gene

Known as: CERP, ATP-BINDING CASSETTE, SUBFAMILY A, MEMBER 1, ABC TRANSPORTER 1 
This gene plays a role in intracellular cholesterol transport.
National Institutes of Health

Related topics

Related topics

11 relations
ABCA1 protein, humanATP Binding Cassette Transporter 1Cholesterol HomeostasisHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Adult microbiota‐deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus
Increasing evidence implicates the microbiota in the regulation of brain and behaviour. Germ‐free mice (GF; microbiota deficient… 
Highly Cited
2014
Highly Cited
2014
Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma
We performed a genome-wide association study for primary open-angle glaucoma (POAG) in 1,007 cases with high-pressure glaucoma… 
Highly Cited
2013
Highly Cited
2013
Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144
Rationale: Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of… 
Highly Cited
2010
Highly Cited
2010
Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway*
Dysfunctional high density lipoprotein (HDL) is implicated in the pathogenesis of cardiovascular disease, but the underlying… 
Highly Cited
2005
Highly Cited
2005
Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease*
Apolipoprotein E (apoE) genotype has a major influence on the risk for Alzheimer disease (AD). Different apoE isoforms may alter… 
Highly Cited
2005
Highly Cited
2005
The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease*
ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be required to maintain normal apoE levels… 
Highly Cited
2005
Highly Cited
2005
Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine.
Highly Cited
2003
Highly Cited
2003
ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer’s disease
Highly Cited
2002
Highly Cited
2002
ABCA1 and Scavenger Receptor Class B, Type I, Are Modulators of Reverse Sterol Transport at an in Vitro Blood-Brain Barrier Constituted of Porcine Brain Capillary Endothelial Cells*
The objective of the present study was to investigate the involvement of key players in reverse cholesterol/24(S)OH-cholesterol… 
Highly Cited
1999
Highly Cited
1999
Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux
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