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Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Retrospective studies have demonstrated that patients who are expressors of cytochrome P4503A5 (CYP3A5) require a higher… 
Highly Cited
2009
Highly Cited
2009
In 2007, a consortium of European experts on tacrolimus (TAC) met to discuss the most recent advances in the drug/dose… 
Highly Cited
2006
Highly Cited
2006
Previous investigations of solid organ transplant patients treated with tacrolimus showed that individuals carrying a CYP3A5*1… 
Review
2003
Review
2003
UNLABELLED Extensive clinical use has confirmed that tacrolimus (Prograf) is a key option for immunosuppression after… 
Review
2002
Review
2002
The clinical management of tacrolimus, a macrolide used as immunosuppressant after transplantation, is complicated by its narrow… 
Highly Cited
1996
Highly Cited
1996
The immunosuppressant drug rapamycin blocks progression of the cell cycle at the G1 phase in mammalian cells and yeast. Here we… 
Review
1993
Review
1993
Tacrolimus (FK 506) is a macrolide immunosuppressant which possesses similar but more potent immunosuppressant properties… 
Highly Cited
1984
Highly Cited
1984
Interleukin 2 promotes proliferation of T cells by virtue of its interaction with a high-affinity cell surface receptor. This…