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Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
  • O. Erel
  • Clinical biochemistry
  • 2005
  • Corpus ID: 35263750
OBJECTIVES To develop a new, colorimetric and automated method for measuring total oxidation status (TOS). DESIGN AND METHODS… Expand
Review
2004
Review
2004
The aim of this review is to analyse critically the recent literature on the clinical pharmacokinetics and pharmacodynamics of… Expand
Highly Cited
2003
Highly Cited
2003
BACKGROUND Transplantation of nonrenal organs is often complicated by chronic renal disease with multifactorial causes. We… Expand
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Highly Cited
2001
Highly Cited
2001
Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling… Expand
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  • figure 4
Review
1997
Review
1997
As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of… Expand
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  • table 5
Review
1997
Review
1997
Background. Tacrolimus (FK506), a macrolide molecule that potently inhibits the expression of interleukin 2 by T lymphocytes… Expand
Highly Cited
1997
Highly Cited
1997
BACKGROUND To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter… Expand
Highly Cited
1996
Highly Cited
1996
A nuclear magnetic resonance (NMR)-based method is described in which small organic molecules that bind to proximal subsites of a… Expand
Review
1995
Review
1995
SummaryTacrolimus, a novel macrocyclic lactone with potent immunosuppressive properties, is currently available as an intravenous… Expand
Review
1992
Review
1992
CsA and FK506 are powerful suppressors of the immune system, most notably of T cells. They act at a point in activation that lies… Expand