Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
UNLABELLED The hepatitis C virus protease inhibitor telaprevir is an inhibitor of the enzyme cytochrome P450 3A, responsible for… (More)
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Highly Cited
2007
Highly Cited
2007
DIRECT (Diabetes Incidence after Renal Transplantation: Neoral C(2) Monitoring Versus Tacrolimus) was a 6-month, open-label… (More)
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Highly Cited
2006
Highly Cited
2006
The chemokine stromal cell-derived factor (SDF-1; also known as chemokine ligand 12 [CXCL12]) regulates many essential biological… (More)
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Review
2006
Review
2006
BACKGROUND Most liver transplant recipients receive either cyclosporin or tacrolimus to prevent rejection. Both drugs inhibit… (More)
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Highly Cited
2001
Highly Cited
2001
Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling… (More)
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Highly Cited
2000
Highly Cited
2000
After the transplantation of unmodified marrow from human leukocyte antigen-matched unrelated donors receiving cyclosporine (CSP… (More)
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Highly Cited
2000
Highly Cited
2000
A series of 32 recipients of liver, kidney, or pancreas transplants who were treated with sirolimus and low-dose tacrolimus… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter… (More)
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Highly Cited
1990
Highly Cited
1990
and Concrete Categories The Joy of Cats Dedicated to Bernhard Banaschewski The newest edition of the file of the present book can… (More)
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