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Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… 
National Institutes of Health

Related topics

Related topics

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Narrower (21)

15,31-desmethyl FK-50631-O-demethyl-FK5069-deoxo-31-O-demethyl-FK506AP 1510
24 HR Tacrolimus 1 MG Extended Release Oral Capsule [Astagraf]24 HR Tacrolimus 1 MG Extended Release Oral Tablet [Envarsus]24 HR Tacrolimus 5 MG Extended Release Oral Capsule [Astagraf]Dermatitis, Atopic

Broader (1)

Immunosuppressive Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Public Health in Norway 1603–2003
Background Honey bees (Apis mellifera) provide a principal example of diphenic development. Excess feeding of female larvae… 
Highly Cited
1996
Highly Cited
1996
Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity (*)
NFAT1 (previously termed NFATp) is a cytoplasmic transcription factor involved in the induction of cytokine genes. We have… 
Highly Cited
1995
Highly Cited
1995
Severe or multiple rejection episodes are associated with early recurrence of hepatitis C after orthotopic liver transplantation
Recurrent hepatitis C causes significant morbidity after liver transplantation. Because immunosuppression is associated with… 
Highly Cited
1993
Highly Cited
1993
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
Nuclear factor of activated T cells (NFAT) is a transcription factor that regulates expression of the cytokine interleukin-2 (IL… 
Highly Cited
1992
Highly Cited
1992
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
Highly Cited
1992
Highly Cited
1992
FK506 binding protein associated with the calcium release channel (ryanodine receptor).
Highly Cited
1992
Highly Cited
1992
Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.
Immunophilins, a family of proteins that exhibit rotamase (peptidyl-prolyl cis-trans isomerase) activity in vitro, are expressed… 
Highly Cited
1988
Highly Cited
1988
Ki‐1 Positive Large Cell Lymphoma: A Morphologic and Immunologic Study of 19 Cases
In this report, we analyze the clinical, morphologic, and immunologic findings of 19 patients with Ki-1 + large cell lymphoma, a… 
Highly Cited
1987
Highly Cited
1987
Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.
The present study shows the in vitro effects of a novel immunosuppressive agent, FK506, in comparison with cyclosporin A (CsA… 
Highly Cited
1984
Highly Cited
1984
Expression of interleukin 2 receptors on activated human B cells
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated… 
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