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Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… 
National Institutes of Health

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Narrower (21)

15,31-desmethyl FK-50631-O-demethyl-FK5069-deoxo-31-O-demethyl-FK506AP 1510
24 HR Tacrolimus 1 MG Extended Release Oral Capsule [Astagraf]24 HR Tacrolimus 1 MG Extended Release Oral Tablet [Envarsus]24 HR Tacrolimus 5 MG Extended Release Oral Capsule [Astagraf]Dermatitis, Atopic

Broader (1)

Immunosuppressive Agents

Papers overview

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Highly Cited
2005
Highly Cited
2005
A Randomized Controlled Trial of Late Conversion from CNI‐Based to Sirolimus‐Based Immunosuppression Following Renal Transplantation
Maintenance immunosuppression with calcineurin inhibitors (CNIs) following renal transplantation is associated with… 
Highly Cited
1992
Highly Cited
1992
A rapamycin-selective 25-kDa immunophilin.
FKBP25, a previously uncharacterized 25-kDa FK506- and rapamycin-binding protein, was purified to homogeneity from calf thymus… 
Highly Cited
1990
Highly Cited
1990
Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways.
We have recently developed a mAb, anti-1F7, which defines a family of structures found to include the molecule recognized by anti… 
Highly Cited
1990
Highly Cited
1990
Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding
SLOW protein-folding reactions are accelerated by a prolyl cis/trans isomerase isolated from porcine kidney1,2 which is… 
Highly Cited
1989
Highly Cited
1989
Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity.
One factor that is critical to the potential effectiveness of radioimmunotherapy is the design of radiometal-chelated antibodies… 
Highly Cited
1986
Highly Cited
1986
Recombinant interferon-gamma induces interleukin 2 receptors on human peripheral blood monocytes.
The present report describes the inducibility of IL 2 receptors on human peripheral blood monocytes. Although freshly isolated… 
Highly Cited
1985
Highly Cited
1985
A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac.
Murine splenocytes immune to influenza virus-activated human T-cells were fused with SP2/0 cells, selected in chemically defined… 
Highly Cited
1984
Highly Cited
1984
Toxicity of an overproduced foreign gene product in Escherichia coli and its use in plasmid vectors for the selection of transcription terminators.
Highly Cited
1984
Highly Cited
1984
Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2.
In certain human IgM and IgG cell lines, immunoglobulin (Ig) secretion is highly stimulated by a B cell inducing factor (BIF… 
Highly Cited
1983
Highly Cited
1983
Mapping of single-stranded regions in duplex DNA at the sequence level: single-strand-specific cytosine methylation in RNA polymerase-promoter complexes.
A method based on the differential rate of cytosine methylation in single- and double-stranded nucleic acids by dimethyl sulfate… 
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