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Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… Expand
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
  • O. Erel
  • Clinical biochemistry
  • 2005
  • Corpus ID: 35263750
OBJECTIVES To develop a new, colorimetric and automated method for measuring total oxidation status (TOS). DESIGN AND METHODS… Expand
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Highly Cited
2005
Highly Cited
2005
Our purposes were to determine the incidence of BK viruria, viremia or nephropathy with tacrolimus (FK506) versus cyclosporine… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Transplantation of nonrenal organs is often complicated by chronic renal disease with multifactorial causes. We… Expand
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Highly Cited
2003
Highly Cited
2003
The calcineurin inhibitors cyclosporine (INN, ciclosporin) and tacrolimus have a narrow therapeutic index and show considerable… Expand
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Highly Cited
2001
Highly Cited
2001
Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Tacrolimus (FK 506) is an effective immunosuppressant drug for the prevention of rejection after organ transplantation… Expand
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Highly Cited
1996
Highly Cited
1996
A nuclear magnetic resonance (NMR)-based method is described in which small organic molecules that bind to proximal subsites of a… Expand
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Highly Cited
1994
Highly Cited
1994
The immunosuppressants rapamycin and FK506 bind to the same intracellular protein, the immunophilin FKBP12. The FKB12-FK506… Expand
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