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Tacrolimus

Known as: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-, Fujimycin 
A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins… 
National Institutes of Health

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Narrower (21)

15,31-desmethyl FK-50631-O-demethyl-FK5069-deoxo-31-O-demethyl-FK506AP 1510
24 HR Tacrolimus 1 MG Extended Release Oral Capsule [Astagraf]24 HR Tacrolimus 1 MG Extended Release Oral Tablet [Envarsus]24 HR Tacrolimus 5 MG Extended Release Oral Capsule [Astagraf]Dermatitis, Atopic

Broader (1)

Immunosuppressive Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Significant improvement in the outcome of HCV-infected transplant recipients by avoiding rapid steroid tapering and potent induction immunosuppression.
Highly Cited
2002
Highly Cited
2002
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells.
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that use 2 major pathways for antigen uptake: constitutive… 
Highly Cited
1995
Highly Cited
1995
FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer.
Despite good initial success in vivo, gene transfer using first-generation replication-defective adenovirus has been reported to… 
Highly Cited
1994
Highly Cited
1994
Very efficient myoblast allotransplantation in mice under FK506 immunosuppression
Transgenic CD1 mice expressing β‐galactosidase were used as myoblast donors. The myoblasts were injected in normal or mdx muscles… 
Highly Cited
1993
Highly Cited
1993
A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments
SummaryA general approach for assigning the resonances of uniformly 15N- and 13C-labeled proteins in their unfolded state is… 
Highly Cited
1993
Highly Cited
1993
Assessment of primary and metastatic ovarian cancer by positron emission tomography (PET) using 2-[18F]deoxyglucose (2-[18F]FDG).
The potential of positron emission tomography (PET) to distinguish benign from malignant ovarian tissue was evaluated by… 
Highly Cited
1990
Highly Cited
1990
Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways.
We have recently developed a mAb, anti-1F7, which defines a family of structures found to include the molecule recognized by anti… 
Highly Cited
1989
Highly Cited
1989
Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity.
One factor that is critical to the potential effectiveness of radioimmunotherapy is the design of radiometal-chelated antibodies… 
Highly Cited
1985
Highly Cited
1985
A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac.
Murine splenocytes immune to influenza virus-activated human T-cells were fused with SP2/0 cells, selected in chemically defined… 
Highly Cited
1985
Highly Cited
1985
Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease.
The phenotypic expression of Hodgkin's and Reed-Sternberg (H-RS) cells was determined by analysis with a panel of monoclonal… 
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