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9-deoxo-31-O-demethyl-FK506

Known as: 9-deoxo-31-O-demethyl-FK-506, 9-deoxo-31-O-demethylFK506 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1963-2017
012319632017

Related topics

Related topics

2 relations

Broader (1)

Tacrolimus
analogs & derivatives

Related mentions per year

Related mentions per year

1950-2018
1960198020002020
9-deoxo-31-O-demethyl-FK506
Tacrolimus
analogs & derivatives

Papers overview

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2015
2015
A phase I open-label study investigating the disposition of [14C]-cabazitaxel in patients with advanced solid tumors.
Cabazitaxel is a semisynthetic taxane approved for the treatment of patients with hormone-refractory metastatic prostate cancer… (More)
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2014
2014
Biotransformation of colchicinoids into their corresponding 3-O-glucosyl derivatives by selected strains of Bacillus megaterium.
Natural colchicinoids and their semisynthetic derivatives are important active ingredients for pharmaceutical applications… (More)
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2014
2014
In vitro microsomal hepatic metabolism of antiasthmatic prototype LASSBio-448.
In this paper, the in vitro microsomal hepatic metabolism of the antiasthmatic prototype LASSBio-448 and the structural… (More)
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2006
2006
Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell
AbstractAim:To study the mechanisms by which N-demethyl-clarithromycin (NDC) induces human cervical cancer HeLa cell apoptosis in… (More)
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2004
2004
The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes.
Pyrazoloacridine (PZA) is an experimental antitumor agent presently under investigation for treatment of solid tumors on the… (More)
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2000
2000
Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid
A series of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4… (More)
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1998
1998
Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes.
1. Roxithromycin and its major metabolites found in rat and human urine, namely the decladinosyl derivative (M1), O-dealkyl… (More)
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1998
1998
Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin.
Roxithromycin has been shown to be a relatively weak inhibitor of cytochrome P450 (P450 or CYP)-dependent drug oxidations… (More)
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1996
1996
Clinical and pharmacokinetic study of oral NK611, a new podophyllotoxin derivative
 NK611 is a novel water-soluble podophyllotoxin derivative that has comparable antitumour activity but higher potency and better… (More)
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Highly Cited
1977
Highly Cited
1977
Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function.
A new, nondestructive, plasma extraction technique ultilizing chloroform:isopropyl alcohol (1:1) and ammonium sulfate saturation… (More)
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