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9-deoxo-31-O-demethyl-FK506

Known as: 9-deoxo-31-O-demethyl-FK-506, 9-deoxo-31-O-demethylFK506 
National Institutes of Health

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2 relations

Broader (1)

Tacrolimus
analogs & derivatives

Papers overview

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2019
2019
Dereplication of podophyllotoxin and related cytotoxic lignans in Hyptis verticillata by ultra-high-performance liquid chromatography tandem mass spectrometry.
INTRODUCTION Hyptis verticillata Jacq. (Lamiaceae) is a Mexican medicinal plant for the treatment of skin infections and illness… 
2014
2014
Biotransformation of Colchicinoids into Their Corresponding 3-O-Glucosyl Derivatives by Selected Strains of Bacillus megaterium
Natural colchicinoids and their semisynthetic derivatives are important active ingredients for pharmaceutical applications… 
2010
2010
Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS.
2004
2004
The Metabolism of Pyrazoloacridine (NSC 366140) by Cytochromes P450 and Flavin Monooxygenase in Human Liver Microsomes
Pyrazoloacridine (PZA) is an experimental antitumor agent presently under investigation for treatment of solid tumors on the… 
2002
2002
Total synthesis of deamido bleomycin a(2), the major catabolite of the antitumor agent bleomycin.
Metabolic inactivation of the antitumor antibiotic bleomycin is believed to be mediated exclusively via the action of bleomycin… 
2002
2002
In vitro metabolism of a novel phosphodiesterase-5 inhibitor DA-8159 in rat liver preparations using liquid chromatography/electrospray mass spectrometry.
The in vitro metabolism of a new erectogenic, DA-8159, has been studied by LC with UV detection and on-line LC-electrospray mass… 
2001
2001
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
We have previously described (RS)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) as a potent agonist at the (RS… 
1993
1993
In vitro embryotoxicity of N-methyl-N-(7-propoxynaphthalene-2-ethyl)hydroxylamine (QAB): evidence for N-dehydroxylated metabolite as a proximate dysmorphogen.
The rat conceptus biotransforms N-methyl-N-(7-propoxynaphthalene-2-ethyl)hydroxylamine (QAB) in vitro to 7-propoxynaphthalen-2… 
1984
1984
Metabolism and pharmacokinetics of metaclazepam (Talis®), Part III: Determination of the chemical structure of metabolites in dogs, rabbits and men
SummaryThe methabolism of 7-bromo-1-methyl-2-methoxymethyl-5-(2′-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine (metaclazepam… 
1980
1980
Metabolism of thymoxamine: identification of metabolites in rat
Thymoxamine hydrochloride administered by mouth to rats at 25 or 100 mg kg−1 was excreted in the urine as the deacetyl and N… 
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