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TSC1 protein, human

Known as: hamartin protein, human, Hamartin, tuberous sclerosis 1 protein, human 
Hamartin (1164 aa, ~130 kDa) is encoded by the human TSC1 gene. This protein is involved in the negative regulation of signaling.
National Institutes of Health

Related topics

Related topics

9 relations
Cell AdhesionCell Proliferation Regulatory ProcessInsulin/Insulin Receptor Signaling PathwayLigand Binding

Broader (1)

Tumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Review
2006
Review
2006
The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.
Review
2006
Review
2006
Hamartin and tuberin modulate gene transcription via β-catenin
SummaryTuberous sclerosis, neurological genetic disorder characterized by the formation of benign tumors or hamartomas in… 
2005
2005
Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin.
Tuberous sclerosis complex (TSC) is a genetic disorder caused by inactivating mutations in the TSC1 or TSC2 genes, which encode… 
Review
2005
Review
2005
The Role of Tuberin in Cellular Differentiation: Are B‐Raf and MAPK Involved?
Abstract: Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome whose manifestations can include seizures, mental… 
Review
2005
Review
2005
Clinical and molecular insights into lymphangioleiomyomatosis.
Lymphangioleiomyomatosis (LAM) is a rare disease of women that is characterized by a proliferation of abnormal smooth muscle-like… 
2003
2003
The tuberin-hamartin complex negatively regulates beta-catenin signaling activity.
Tuberous sclerosis complex (TSC) is characterized by the formation of hamartomas in multiple organs resulting from mutations in… 
2003
2003
Lissencephaly with agenesis of corpus callosum and rudimentary dysplastic cerebellum: a subtype of lissencephaly with cerebellar hypoplasia
Lissencephaly with agenesis of the corpus callosum and rudimentary dysplastic cerebellum may represent a subset of lissencephaly… 
2002
2002
Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin.
2001
2001
Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex.
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