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TPMT gene

Known as: THIOPURINE S-METHYLTRANSFERASE, TPMT, Thiopurine S-Methyltransferase Gene 
This gene plays a role in the metabolism of thiopurine drugs.
National Institutes of Health

Related topics

Related topics

6 relations
MethylationNucleotide MetabolismThiopurine S methyltranferase deficiencyThiopurine S-Methyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Thiopurine S-methyltransferase (TPMT) Activity Is Better Determined by Biochemical Assay Versus Genotyping in the Jewish Population
BackgroundThiopurine S-methyltransferase (TPMT) is a key enzyme that deactivates thiopurines, into their inactive metabolite, 6… 
Highly Cited
2011
Highly Cited
2011
A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine.
BACKGROUND AND AIMS Pharmacogenetic studies in inflammatory bowel diseases (IBD) are mainly focused on genes involved in the… 
2009
2009
Genetic polymorphisms of thiopurine S-methyltransferase in a cohort of patients with systemic autoimmune diseases.
OBJECTIVES Azathioprine (AZA) is a purine antimetabolite, prodrug widely used as a disease modifying drug in several rheumatic… 
2006
2006
Frequency of the thiopurine S‐methyltransferase alleles in the ancient genetic population isolate of Sardinia
Background:  Thiopurine S‐methyltransferase (TPMT) is an enzyme involved in the normal metabolic inactivation of thiopurine drugs… 
2005
2005
The Impact of Thiopurine S-Methyltransferase Polymorphism on Azathioprine-Induced Myelotoxicity in Renal Transplant Recipients
Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine… 
2004
2004
Rapid, long-range molecular haplotyping of thiopurine S-methyltransferase (TPMT) *3A, *3B, and *3C.
BACKGROUND Haplotyping is an important technique in molecular diagnostics because haplotypes are often more predictive for… 
Highly Cited
2003
Highly Cited
2003
In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase.
2003
2003
Phenotypic and Genotypic Analysis of Thiopurine S‐Methyltransferase Polymorphism in the Bulgarian Population
&NA; Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine… 
Highly Cited
2003
Highly Cited
2003
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL 
Highly Cited
2002
Highly Cited
2002
Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations.
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. In Caucasians, four variant TPMT alleles… 
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