TPMT gene

Known as: THIOPURINE S-METHYLTRANSFERASE, TPMT, Thiopurine S-Methyltransferase Gene 
This gene plays a role in the metabolism of thiopurine drugs.
National Institutes of Health

Papers overview

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2013
2013
Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. A serious complication of cisplatin… (More)
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2008
2008
Individuals with intermediate or no thiopurine S-methyltransferase (TPMT) activity are at risk of hematotoxicity when treated… (More)
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2007
2007
6-Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL… (More)
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2005
2005
Human thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. TPMT is genetically polymorphic and… (More)
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Highly Cited
2003
Highly Cited
2003
AIMS The goal of this study was to determine the frequencies of important allelic variants in the TPMT, NAT2, GST, SULT1A1 and… (More)
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2003
2003
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of thiopurines (eg 6-mercaptopurine… (More)
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2003
2003
Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine toxicity… (More)
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Highly Cited
1999
Highly Cited
1999
The molecular basis for the genetic polymorphism of thiopurine S -methyltransferase (TPMT) has been estab-lished for Caucasians… (More)
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Highly Cited
1999
Highly Cited
1999
Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercapto-purine, 6-thioguanine and… (More)
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1996
1996
Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that catalyzes the S-methylation of the cytotoxic drugs 6… (More)
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