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TPMT gene

Known as: THIOPURINE S-METHYLTRANSFERASE, TPMT, Thiopurine S-Methyltransferase Gene 
This gene plays a role in the metabolism of thiopurine drugs.
National Institutes of Health

Related topics

Related topics

6 relations
MethylationNucleotide MetabolismThiopurine S methyltranferase deficiencyThiopurine S-Methyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon
Supplemental Digital Content is available in the text. Reduced function alleles in the TPMT and NUDT15 genes are risk factors for… 
2014
2014
Thiopurine S-methyltransferase (TPMT) Activity Is Better Determined by Biochemical Assay Versus Genotyping in the Jewish Population
BackgroundThiopurine S-methyltransferase (TPMT) is a key enzyme that deactivates thiopurines, into their inactive metabolite, 6… 
2013
2013
Análisis de los polimorfismos génicos de Tiopurina S-Metiltransferasa (TPMT) en pacientes pediátricos mexicanos con cáncer
La Tiopurina S-Metiltransferasa (TPMT) cataliza la S-metilacion de tiopurinas como la 6-mercaptopurina, 6-tioguanina y… 
Highly Cited
2011
Highly Cited
2011
A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine.
BACKGROUND AND AIMS Pharmacogenetic studies in inflammatory bowel diseases (IBD) are mainly focused on genes involved in the… 
2011
2011
Screening of TPMT Deficiency by Phenotyping and Genotyping: A Retrospective Study Among 1,500 IBD Patients in France
2006
2006
Frequency of the thiopurine S‐methyltransferase alleles in the ancient genetic population isolate of Sardinia
Background:  Thiopurine S‐methyltransferase (TPMT) is an enzyme involved in the normal metabolic inactivation of thiopurine drugs… 
2005
2005
The Impact of Thiopurine S-Methyltransferase Polymorphism on Azathioprine-Induced Myelotoxicity in Renal Transplant Recipients
Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine… 
2004
2004
Rapid, long-range molecular haplotyping of thiopurine S-methyltransferase (TPMT) *3A, *3B, and *3C.
BACKGROUND Haplotyping is an important technique in molecular diagnostics because haplotypes are often more predictive for… 
2003
2003
Phenotypic and Genotypic Analysis of Thiopurine S‐Methyltransferase Polymorphism in the Bulgarian Population
&NA; Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine… 
Highly Cited
2003
Highly Cited
2003
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL 
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