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TP63 protein, human

Known as: p73L, TP73L protein, human, Chronic Ulcerative Stomatitis Protein 
Tumor protein 63 (680 aa, ~77 kDa) is encoded by the human TP63 gene. This protein plays a role in the mediation of both transcription and limb… 
National Institutes of Health

Related topics

Related topics

16 relations
ApoptosisDNA-Binding ProteinsGenes, RegulatorHomo sapiens

Broader (3)

TP63 wt AlleleTRANSCRIPTION FACTORTumor Suppressor Proteins

Narrower (2)

Tumor Protein 63 Isoform 2, humanp63alpha protein, human

Papers overview

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2019
2019
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival… 
2016
2016
Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes TP63 and CD40 with Risk for Lung Cancer in a Chinese Han Population.
Apoptosis plays a critical role in tumorigenesis. TP63 inhibits the pro-apoptosis function of TP53, and CD40 increases expression… 
Review
2014
Review
2014
New advances in the pathogenesis and progression of barrett's esophagus.
Barrett's esophagus (BE) is a premalignant condition in the esophagus, with a rising incidence rate among Caucasians, and an… 
2013
2013
EEC‐ and ADULT‐Associated TP63 Mutations Exhibit Functional Heterogeneity Toward P63 Responsive Sequences
TP63 germ‐line mutations are responsible for a group of human ectodermal dysplasia syndromes, underlining the key role of P63 in… 
2013
2013
Tumor Protein p63/microRNA Network in Epithelial Cancer Cells
Non-coding microRNAs are involved in multiple regulatory mechanisms underlying response of cancer cells to stress leading to… 
2013
2013
[Changes in the innervation of the taste buds in diabetic rats].
INTRODUCTION Abnormal sensations such as pain and impairment of taste are symptoms of approximately 10% of patients having… 
2011
2011
TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression
The ΔNp63 protein, a product of the TP63 gene that lacks the N-terminal domain, has a critical role in the maintenance of self… 
2010
2010
Phosphorylated TP63 Induces Transcription of RPN13, Leading to NOS2 Protein Degradation*
Head and neck squamous cell carcinoma cells exposed to cisplatin display ATM-dependent phosphorylation of the most predominant… 
2008
2008
Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa.
OBJECTIVE The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the… 
2002
2002
CUSP/p63 expression in basal cell carcinoma
Abstract: Chronic ulcerative stomatitis protein (CUSP), the most abundant cutaneous isoform of p63, is a p53‐related gene… 
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