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TP53BP2 gene

Known as: tumor protein p53 binding protein 2, TP53BP2, TUMOR PROTEIN p53-BINDING PROTEIN 2 
This gene plays an inhibitory role in G2/M cell cycle progression and stimulates the transactivation of pro-apoptotic genes.
National Institutes of Health

Related topics

Related topics

5 relations
ApoptosisNegative Regulation of G2 to M TransitionRegulation of Cell Death ProcessTumor Protein p53 Binding Protein 2

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TP53BP2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Expression of apoptosis-stimulating protein of p53 family members in invasive breast cancer and its prognostic significance
Objective To explore the expression of apoptosis-stimulating protein of p53 (ASPP) family members in invasive breast cancer and… 
2017
2017
Structural characterization of the ASPP/PP1 phosphatase complex
Serine/Threonine phosphatases such as PP1 generally lack substrate specificity and associate with a large array of targeting… 
2010
2010
The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity
ASPP2 has been identified as a haploinsufficient tumour suppressor in mice, and an activator of the apoptotic function of the p53… 
2010
2010
The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity
2010
2010
Detection and significance of p53 and ASPP2 gene mutation in primary liver cancer
OBJECTIVE:To detect p53 and ASPP2 gene mutations and evaluate their significance.METHODS:A total of 24 cases of primary hepatic… 
2009
2009
Apoptosis: Dodging death
stimulating protein of p53 2 (ASPP2, also known as TP53BP2) is often reduced in many human cancers, and a growing body of… 
2009
2009
Genetics of gene expression: Putting radiation response on the map
2007
2007
Original paper The leukemogenic role of (iASPP) in acute leukemia
Introduction: The ASPP family (apoptosis – stimulating proteins of p53) comprises three proteins, ASPP1, ASPP2 and iASPP, that… 
Review
2005
Review
2005
E2F and p53 make a nice couple: converging pathways in apoptosis
It has been known for some time that p53 activation elicits growth arrest in normal cells, whereas activation of this tumor… 
Review
2003
Review
2003
Structure Watch
NATURE REVIEWS | MOLECULAR CELL BIOLOGY VOLUME 4 | FEBRUARY 2003 | 87 The ability of p53 to induce apoptosis is a key defence…