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TP53BP2 gene

Known as: tumor protein p53 binding protein 2, TP53BP2, TUMOR PROTEIN p53-BINDING PROTEIN 2 
This gene plays an inhibitory role in G2/M cell cycle progression and stimulates the transactivation of pro-apoptotic genes.
National Institutes of Health

Related topics

Related topics

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ApoptosisNegative Regulation of G2 to M TransitionRegulation of Cell Death ProcessTumor Protein p53 Binding Protein 2

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TP53BP2 wt Allele

Papers overview

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2019
2019
ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a large array of targeting subunits to… 
Highly Cited
2014
Highly Cited
2014
ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1
Epithelial to mesenchymal transition (EMT), and the reverse mesenchymal to epithelial transition (MET), are known examples of… 
Highly Cited
2014
Highly Cited
2014
CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2
Apoptosis-stimulating protein of p53-2 (ASPP2) induces apoptosis by promoting the expression of pro-apoptotic genes via binding… 
Highly Cited
2008
Highly Cited
2008
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2
We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic… 
Review
2007
Review
2007
ASPP: a new family of oncogenes and tumour suppressor genes
The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins… 
Highly Cited
2006
Highly Cited
2006
ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This… 
Highly Cited
2005
Highly Cited
2005
Tumor Gene Expression and Prognosis in Breast Cancer Patients with 10 or More Positive Lymph Nodes
Purpose: This study, along with two others, was done to develop the 21-gene Recurrence Score assay (Oncotype DX) that was… 
Highly Cited
2003
Highly Cited
2003
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated… 
Highly Cited
2002
Highly Cited
2002
Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites
The tumor suppressor protein p53, once activated, can cause either cell cycle arrest or apoptosis through transactivation of… 
Highly Cited
1996
Highly Cited
1996
The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M
Using the yeast two-hybrid system, we have isolated a cDNA (designated BBP, for Bcl2-binding protein) for a protein (Bbp) that… 
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