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TP53BP2 gene

Known as: tumor protein p53 binding protein 2, TP53BP2, TUMOR PROTEIN p53-BINDING PROTEIN 2 
This gene plays an inhibitory role in G2/M cell cycle progression and stimulates the transactivation of pro-apoptotic genes.
National Institutes of Health

Related topics

Related topics

5 relations
ApoptosisNegative Regulation of G2 to M TransitionRegulation of Cell Death ProcessTumor Protein p53 Binding Protein 2

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TP53BP2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
miR-219a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury via Impairing TP53BP2
BackgroundHepatic ischemia/reperfusion (I/R) injury is a serious complication that occurs upon hypovolemic shock, liver resection… 
2015
2015
Clustering protein-protein interaction network of TP53 tumor suppressor protein using Markov clustering algorithm
The formation and proliferation of tumor cells occurs if a special protein that regulates cell division experience any changing… 
2010
2010
Mutational Analysis of ASPP1 and ASPP2 Genes, a p53-related Gene, in Gastric and Cololorectal Cancers with Microsatellite Instability.
To the editor, In most human cancers, functions of p53 tumor suppressor are inactivated by many mechanisms, most commonly by… 
Review
2009
Review
2009
New insights into the expanding complexity of the tumor suppressor ASPP2
Apoptosis Stimulating Protein of p53-2, ASPP2, aka 53BP2L, (encoded by TP53BP2) is a pro-apoptotic member of a family of p53… 
2007
2007
Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.
Review
2007
Review
2007
Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2.
ASPP (apoptosis-stimulating protein of p53) 2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response… 
2006
2006
Effects of Oncogenic Mutations and DNA Response Elements on the Binding of p53 to p53-binding Protein 2 (53BP2)*
The tumor suppressor p53 is frequently mutated in human cancers. Upon activation it can induce cell cycle arrest or apoptosis… 
2005
2005
TP53BP2 locus is associated with gastric cancer susceptibility
We investigated the association of the TP53BP2 locus with gastric cancer susceptibility in a Korean population. We assayed 9… 
2004
2004
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
2001
2001
p53-interacting protein 53BP2 inhibits clonogenic survival and sensitizes cells to doxorubicin but not paclitaxel-induced apoptosis
53BP2 was initially identified as a protein interacting with p53 in a yeast two-hybrid screen and subsequently shown to enhance… 
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