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SCOP database in 2004: refinements integrate structure and sequence family data
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domainsExpand
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Data growth and its impact on the SCOP database: new developments
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. The SCOPExpand
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SCOP2 prototype: a new approach to protein structure mining
We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.mrc-lmb.cam.ac.uk/), that we have developed recently. SCOP2 is a successor to the Structural ClassificationExpand
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Structures of SAS-6 Suggest Its Organization in Centrioles
Self-assembly of a centriolar protein may contribute to organizing the cartwheel-like hub and establishing centriole symmetry. Centrioles are cylindrical, ninefold symmetrical structures withExpand
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Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with smallExpand
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A bimodular mechanism of calcium control in eukaryotes
Calcium ions (Ca2+) have an important role as secondary messengers in numerous signal transduction processes, and cells invest much energy in controlling and maintaining a steep gradient betweenExpand
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The structural basis for catalysis and substrate specificity of a rhomboid protease
Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes asExpand
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SISYPHUS—structural alignments for proteins with non-trivial relationships
With the increasing amount of structural data, the number of homologous protein structures bearing topological irregularities is steadily growing. These include proteins with circular permutations,Expand
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Revised structure of the AbrB N‐terminal domain unifies a diverse superfamily of putative DNA‐binding proteins
New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N‐terminal, DNA‐binding domain of theExpand
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Evolution of protein fold in the presence of functional constraints.
The functional requirement to form and maintain the active site structure probably exerts a strong selective pressure on a protein to adopt just one stable and evolutionarily conserved fold.Expand
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