Skip to search formSkip to main contentSkip to account menu

TNF Receptor-Associated Death Domain Protein

Known as: TNF Receptor Associated Death Domain Protein, TNFR1-Associated Death Domain Protein, TNF Receptor-Associated Death Domain Protein [Chemical/Ingredient] 
TRADD is an adaptor protein involved in the recruitment of FADD or TRAF signaling proteins into TNF-stimulated cell death or NFKB induction. TRADD… 
National Institutes of Health

Related topics

Related topics

22 relations
Adaptor Signaling Protein GeneApoptosisApoptosis PromoterDR3 and DR4/5 Mediated Apoptosis Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Highly Cited
2007
Highly Cited
2007
γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of…
Unlike the tocopherols, the tocotrienols, also members of the vitamin E family, have an unsaturated isoprenoid side chain. In… 
Highly Cited
2007
Highly Cited
2007
MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling
Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The… 
Highly Cited
2007
Highly Cited
2007
Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-κB-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and…
Fisetin (3,7,3′,4′-tetrahydroxyflavone) exhibits anti-inflammatory and antiproliferative effects through a mechanism that is… 
Highly Cited
2004
Highly Cited
2004
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles.
Highly Cited
2003
Highly Cited
2003
Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
Highly Cited
2003
Highly Cited
2003
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation.
Engagement of TNF receptor 1 by TNFalpha activates the transcription factor NF-kappaB but can also induce apoptosis. Here we show… 
Review
2002
Review
2002
Apoptotic signaling pathways: caspases and stress-activated protein kinases.
Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the… 
Highly Cited
2000
Highly Cited
2000
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
Highly Cited
1999
Highly Cited
1999
Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling*
The 55-kDa receptor for tumor necrosis factor (TR55) triggers multiple signaling cascades initiated by adapter proteins like… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)