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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Cardif is described, a new CARD-containing adaptor protein that interacts with RIG-I and recruits IKKα, IKKβ and IKKɛ kinases by means of its C-terminal region, leading to the activation of NF-κB and IRF3.
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.
Intracellular pattern recognition receptors in the host response
It is apparent that Toll-like receptors, a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen signalling cascades, are likely to have critical roles in health and disease.
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
This work investigated the 'downstream' signaling events that regulate TLR3-dependent Trif-induced NF-kappa B activation and found that RIP1 mediates Trif’s NF-Kappa Bactivation through its RIP homotypic interaction motif.
RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation
This work investigated the 'downstream' signaling events that regulate TLR3-dependent Trif-induced NF-κB activation and found that RIP1 mediates Trif -RIP1–inducedNF-κBs activation.
Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses.
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
It is shown that the NF-κB pathway is required for the development of tumours in a mouse model of lung adenocarcinoma and that this requirement depends on p53 status, and that inhibition of the pathway in lung tumouring in vivo resulted in significantly reduced tumour development.