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TIF2 factor, human

Known as: TIF2, bHLHe75, Class E Basic Helix-Loop-Helix Protein 75 
Nuclear receptor coactivator 2 (1464 aa, ~159 kDa) is encoded by the human NCOA2 gene. This protein plays a role in the regulation of steroid… 
National Institutes of Health

Related topics

Related topics

17 relations
Androgen Receptor Regulation PathwayCell Differentiation processCell Fate ControlCell Nucleus

Broader (1)

glucocorticoid receptor-interacting protein 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin.
The androgen receptor (AR) is an important signaling molecule in multiple tissues, yet its mode of action and cell-specific… 
2006
2006
Conformational changes of the glucocorticoid receptor ligand binding domain induced by ligand and cofactor binding, and the location of cofactor binding sites determined by hydrogen/deuterium…
HXMS (hydrogen/deuterium exchange mass spectrometry) of the glucocorticoid receptor ligand‐binding domain (GR LBD) complexed with… 
2005
2005
The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.
Recent structural analyses of the nuclear receptors establish a paradigm of receptor activation, in which agonist binding induces… 
2004
2004
Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.
The liver receptor homolog 1 (LRH-1) belongs to the Fushi tarazu factor 1 nuclear receptor subfamily, and its biological… 
Highly Cited
2004
Highly Cited
2004
Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).
Antiandrogens are widely used agents in the treatment of prostate cancer, as inhibitors of AR (androgen receptor) action… 
2002
2002
Modulation of Induction Properties of Glucocorticoid Receptor-Agonist and -Antagonist Complexes by Coactivators Involves Binding to Receptors but Is Independent of Ability of Coactivators to Augment…
Coactivators such as TIF2 and SRC-1 modulate the positioning of the dose-response curve for agonist-bound glucocorticoid… 
2002
2002
Coactivation of an endogenous progesterone receptor by TIF2 in COS-7 cells.
2001
2001
DNA Binding-independent Transcriptional Activation by the Androgen Receptor through Triggering of Coactivators*
Androgens have critical roles in the development and maintenance of the male reproductive system and are important for… 
2000
2000
Evidence for a Common Step in Three Different Processes for Modulating the Kinetic Properties of Glucocorticoid Receptor-induced Gene Transcription*
The dose-response curve of steroid hormones and the associated EC50 value are critical parameters both in the development of new… 
Highly Cited
2000
Highly Cited
2000
Retinoic Acid Stimulation of the Human Surfactant Protein B Promoter Is Thyroid Transcription Factor 1 Site-dependent*
Surfactant B (SP-B) is a 79-amino acid peptide critical to postnatal respiratory adaptation. Expression of SP-B by respiratory… 
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