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A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
TLDR
It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that sPermatocyte/spermatid development/survival critically depends on androgens.
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Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins.
TLDR
The hypothesis that SREBPs are involved in the coordinate regulation of lipogenic gene expression by androgens is supported and evidence for the existence of a cascade mechanism of androgen-regulated gene expression is provided.
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Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
TLDR
Findings indicate that increased FAS expression is one of the earliest and most common events in the development of prostate cancer, suggesting that FAS may be used as a general prostate cancer marker and that antineoplastic therapy based on FAS inhibition may be an option for chemoprevention or curative treatment for nearly all prostate cancers.
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Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
TLDR
It is demonstrated that in LNCaP prostate cancer cells FAS expression is markedly elevated by androgens via an indirect pathway involving sterol regulatory element-binding proteins (SREBPs), and that growth factors such as EGF are able to stimulate FAS mRNA, protein and activity.
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Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.
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Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.
TLDR
Data demonstrate that androgens, mediated by the androgen receptor, stimulate the expression and activity of FAS and suggest that stimulation of Fas activity represents at least part of the mechanism by which androgens induce the accumulation of neutral lipids in LNCaP cells.
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Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding…
TLDR
Time course studies and overexpression experiments showing that increasing levels of SCAP enhance the production of mature SREBP and stimulate lipogenic gene expression support the contention that SCAP plays a pivotal role in the lipogenic effects of androgens in tumor cells.
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Androgens, lipogenesis and prostate cancer
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Advances in Brief Role of the Phosphatidylinositol 3-Kinase / PTEN / Akt Kinase Pathway in the Overexpression of Fatty Acid Synthase in LNCaP Prostate Cancer Cells 1
TLDR
Results demonstrate that inactivation of PTEN and subsequent activation of the PI3k/Akt kinase pathway may play an important role in the overexpression of the FAS protein in cancer cells.
E2F activity is biphasically regulated by androgens in LNCaP cells.
TLDR
The results indicate that the biphasic dose response of LNCaP proliferation to androgen is closely reflected in Rb phosphorylation, E2F activity and p27(KIP1) protein expression.
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