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TGFBR1 gene

Known as: ALK-5, ACTIVIN RECEPTOR-LIKE KINASE 5, TGFBR1 
This gene is involved in transcriptional regulation and cell cycle progression regulation.
National Institutes of Health

Related topics

Related topics

9 relations
Cell Cycle ProgressionLigand BindingPhosphorylationReceptor Signaling

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TGFBR1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Efficacy of ALK 5 inhibition in myelofibrosis
1Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. 2Department of Hematology… 
2017
2017
ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles.
2016
2016
FGF 2 inhibits endothelial-mesenchymal transition through microRNA-20 a-mediated repression of canonical TGF-beta signaling
Endothelial-to-mesenchymal transition (EndMT) is characterized by the loss of endothelial cell markers and functions, and… 
2014
2014
Antibacterials for any target
RNA-guided nucleases provide a strategy for killing specific bacterial species in complex populations. 
2013
2013
Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles as inhibitors of transforming growth factor-β type I receptor (ALK5).
2009
2009
Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5).
2009
2009
The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer
A polymorphic 9-bp deletion in exon 1 of TGFBR1 (TGFBR1*6A) has been identified as a low-penetrance cancer susceptibility allele… 
2005
2005
Adopting a Practical Statistical Approach for Evaluating Assay Agreement in Drug Discovery
The authors assess the equivalence of 2 assays and put forward a general approach for assay agreement analysis that can be… 
1998
1998
A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice.
TGF beta family members are implicated in cardiac organogenesis, growth control, and positional information, including the… 
1995
1995
Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3.
GH3 pituitary tumor cells have surface receptors for transforming growth factors-beta (TGF-beta s) and activins/inhibins. GH3… 
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