Cell Cycle Progression

The cell cycle is an ordered set of events. Progression through the stages of cell cycle, including G1-S-G2-M, culminates in cell growth and division… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non… (More)
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Review
2006
Review
2006
The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor… (More)
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Review
2003
Review
2003
As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer therapeutic target. Recent… (More)
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Review
2003
Review
2003
The PI3K/Akt signal transduction cascade has been investigated extensively for its roles in oncogenic transformation. Initial… (More)
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Highly Cited
2002
Highly Cited
2002
The E2F transcription factor family is known to play a key role in the timely expression of genes required for cell cycle… (More)
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Highly Cited
1999
Highly Cited
1999
To investigate the molecular basis of PTEN-mediated tumor suppression, we introduced a null mutation into the mouse Pten gene by… (More)
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Highly Cited
1996
Highly Cited
1996
While interactions between CD28 and members of the B7 family costimulate and enhance T cell responses, recent evidence indicates… (More)
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Highly Cited
1995
Highly Cited
1995
Members of the Rho family of small guanosine triphosphatases (GTPases) regulate the organization of the actin cytoskeleton; Rho… (More)
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Highly Cited
1993
Highly Cited
1993
A cascade of events is triggered upon the addition of growth factor to quiescent mammalian cells, which ultimately restarts… (More)
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Highly Cited
1992
Highly Cited
1992
Gene amplification occurs at high frequency in transformed cells (10(-3)-10(-5)), but is undetectable in normal diploid… (More)
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