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TFF1 protein, human

Known as: breast cancer-estrogen induced protein, human, Gastrointestinal Trefoil Protein PS2, Trefoil Protein 1 
Trefoil factor 1 (84 aa, ~9 kDa) is encoded by the human TFF1 gene. This protein is involved in the maintenance of the gastrointestinal mucosa.
National Institutes of Health

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Highly Cited
2002
Highly Cited
2002
The human trefoil protein TFF1 is a small cysteine‐rich secreted protein that is frequently expressed in breast tumors under the… Expand
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Highly Cited
2002
Highly Cited
2002
Background Trefoil peptides (TFFs) are expressed and secreted in a tissue‐specific manner in the gastrointestinal tract. Evidence… Expand
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Highly Cited
2000
Highly Cited
2000
The expression of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6) has previously been described in… Expand
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Highly Cited
2000
Highly Cited
2000
Endoproteolysis of β-amyloid precursor protein (βAPP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS Trefoil factors (TFFs) are secreted gastrointestinal proteins that have been shown to protect and promote… Expand
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Highly Cited
1999
Highly Cited
1999
Alzheimer’s disease is characterized by neurodegeneration and deposition of βA4, a peptide that is proteolytically released from… Expand
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Highly Cited
1998
Highly Cited
1998
Mutations in two related genes, presenilin 1 and 2 presenilin 2 (PS1 and PS2), cosegregate with Alzheimer's disease. PS1 and PS2… Expand
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Highly Cited
1997
Highly Cited
1997
Mutations in two related genes, PS1and PS2, account for the majority of early onset cases of familial Alzheimer’s disease. PS1… Expand
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Highly Cited
1988
Highly Cited
1988
The human pS2 gene is specifically expressed under estrogen transcriptional control in a subclass of estrogen receptor-containing… Expand
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Highly Cited
1978
Highly Cited
1978
1. A study has been made of the tension responses and sarcomere length changes produced by servo‐controlled stretches applied to… Expand
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