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TERF2 protein, human

Known as: Telomeric Repeat Binding Factor 2, TTAGGG repeat-binding factor 2, human, TRF2 protein, human 
Telomeric repeat-binding factor 2 (500 aa, ~56 kDa) is encoded by the human TERF2 gene. This protein plays a role in telomere maintenance.
National Institutes of Health

Related topics

Related topics

13 relations
DNA Binding DomainDNA-Binding ProteinsLigand BindingShelterin

Broader (1)

Telomeric Repeat Binding Protein 2

Papers overview

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Highly Cited
2020
Highly Cited
2020
Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether… 
Highly Cited
2018
Highly Cited
2018
GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability
The list of long non-coding RNAs (lncRNAs) involved in the p53 pathway of the DNA damage response is rapidly expanding, but… 
Highly Cited
2014
Highly Cited
2014
TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres.
2010
2010
[Telomeres in the brain cortex of depressive patients].
Highly Cited
2009
Highly Cited
2009
Multiple roles for Mre11 at uncapped telomeres
Progressive telomere attrition or uncapping of the shelterin complex elicits a DNA damage response as a result of a cell’s… 
Highly Cited
2007
Highly Cited
2007
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
When telomeres are rendered dysfunctional through replicative attrition of the telomeric DNA or by inhibition of shelterin, cells… 
Highly Cited
2005
Highly Cited
2005
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.
Telomerase represents an attractive target for a mechanism-based therapeutic approach because its activation has been associated… 
Highly Cited
2004
Highly Cited
2004
Nucleolar localization of the human telomeric repeat binding factor 2 (TRF2)
The telomeric repeat binding factor 2 (TRF2) specifically recognizes TTAGGG tandem repeats at chromosomal ends. Unexpectedly… 
Highly Cited
2002
Highly Cited
2002
Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication.
Highly Cited
1999
Highly Cited
1999
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
Although broken chromosomes can induce apoptosis, natural chromosome ends (telomeres) do not trigger this response. It is shown… 
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