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Shelterin

Known as: Shelterin Complex, Telosome 
A protein complex that is physically bound to chromosomal telomeres and plays a role in both the elongation and maintenance of telomeric repeats.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been… Expand
Review
2018
Review
2018
  • T. de Lange
  • Annual review of genetics
  • 2018
  • Corpus ID: 52193332
For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been… Expand
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Review
2017
Review
2017
Martínez and Blasco review the molecular mechanisms underlying diseases associated with telomere dysfunction, including… Expand
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Highly Cited
2012
Highly Cited
2012
Not Broken Until Repaired Humans, and indeed most eukaryotes, have linear chromosomes with two DNA ends, known as telomeres… Expand
Highly Cited
2009
Highly Cited
2009
Human telomeres bind shelterin, the six-subunit protein complex that protects chromosome ends from the DNA damage response and… Expand
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Review
2008
Review
2008
The genomes of prokaryotes and eukaryotic organelles are usually circular as are most plasmids and viral genomes. In contrast… Expand
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Highly Cited
2008
Highly Cited
2008
Patients with dyskeratosis congenita (DC), a heterogeneous inherited bone marrow failure syndrome, have abnormalities in telomere… Expand
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Highly Cited
2008
Highly Cited
2008
We describe a novel synthetic small molecule which shows an unprecedented stabilization of the human telomeric G-quadruplex with… Expand
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Review
2005
Review
2005
Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific… Expand
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Highly Cited
2004
Highly Cited
2004
In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial roles in telomere biology. They interact with several… Expand
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