Shelterin

Known as: Shelterin Complex, Telosome 
A protein complex that is physically bound to chromosomal telomeres and plays a role in both the elongation and maintenance of telomeric repeats.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2017
020406019782017

Papers overview

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Highly Cited
2012
Highly Cited
2012
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require… (More)
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Highly Cited
2010
Highly Cited
2010
Human telomeres bind shelterin, the six-subunit protein complex that protects chromosome ends from the DNA damage response and… (More)
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2010
2010
The symphony of the human genome concludes with a long Gregorian chant of TTAGGG repeats. This monotonous coda represents one of… (More)
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Highly Cited
2009
Highly Cited
2009
Telomeres protect chromosome ends through the interaction of telomeric repeats with shelterin, a protein complex that represses… (More)
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Highly Cited
2008
Highly Cited
2008
Patients with dyskeratosis congenita (DC), a heterogeneous inherited bone marrow failure syndrome, have abnormalities in telomere… (More)
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Highly Cited
2008
Highly Cited
2008
Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting… (More)
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Highly Cited
2007
Highly Cited
2007
When telomeres are rendered dysfunctional through replicative attrition of the telomeric DNA or by inhibition of shelterin, cells… (More)
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Highly Cited
2007
Highly Cited
2007
Telomeres were originally defined as chromosome caps that prevent the natural ends of linear chromosomes from undergoing… (More)
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Highly Cited
2007
Highly Cited
2007
Telomere dysfunction may result in chromosomal abnormalities, DNA damage responses, and even cancer. Early studies in lower… (More)
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Highly Cited
2004
Highly Cited
2004
In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial roles in telomere biology. They interact with several… (More)
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