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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
- G. Steinbach, P. Lynch, +21 authors G. Kelloff
- The New England journal of medicine
- 29 June 2000
In patients with familial adenomatous polyposis, six months of twice-daily treatment with 400 mg of celecoxib, a cyclooxygenase-2 inhibitor, leads to a significant reduction in the number of colorectal polyps. Expand
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene…
It is shown that EGF induces EGFR-expressing cancer cells to undergo a transition from the epithelial to the spindle-like mesenchymal morphology and induce cancer cell EMT via STAT3-mediated TWIST gene expression. Expand
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
A better understanding of drug resistance mechanisms is required to improve outcomes in patients with pancreatic cancer. Here, we characterized patterns of sensitivity and resistance to three… Expand
Borderline Resectable Pancreatic Cancer: Definitions, Management, and Role of Preoperative Therapy
Patients with favorable responses to preoperative therapy are the subset of patients who have the best chance for an R0 resection and a favorable long-term outcome. Expand
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer. Expand
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.
Molecular evidence is provided showing that the activation of Notch signaling is mechanistically linked with chemoresistance phenotype (EMT phenotype) of PC cells, suggesting that the inactivation of notch signaling by novel strategies could be a potential targeted therapeutic approach for overcoming chemores resistance toward the prevention of tumor progression and/or treatment of metastatic PC. Expand
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
Blockade of activated Stat3 via ectopic expression of dominant-negative Stat3 significantly suppressed VEGF expression, angiogenesis, tumor growth, and metastasis in vivo, suggesting that Stat3 signaling may be targeted for treatment of pancreatic cancer. Expand
Despite pancreatic cancer's resistance to currently available treatments, new methods are being investigated and new therapeutic strategies based on the molecular biology of Pancreatic cancer seem to hold the greatest promise. Expand
Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus
A significant synergy between heavy alcohol consumption, hepatitis virus infection, and diabetes mellitus may suggest a common pathway for hepatocarcinogenesis in high‐risk individuals. Expand
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma.
- M. Ratain, T. Eisen, +13 authors P. O'dwyer
- Journal of clinical oncology : official journal…
- 1 June 2006
Sorafenib has significant disease-stabilizing activity in metastatic renal cell carcinoma and is tolerable with chronic daily therapy. Expand