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TD-4208

 
National Institutes of Health

Papers overview

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2018
2018
Pharmacodynamics, pharmacokinetics and safety of revefenacin (TD-4208), a long-acting muscarinic antagonist, in patients with chronic obstructive pulmonary disease (COPD): Results of two randomized…
BACKGROUND Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist currently in development as a… Expand
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2018
2018
Pharmacological properties of revefenacin (TD‐4208), a novel, nebulized long‐acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and…
Abstract Revefenacin (TD‐4208) is a novel, long‐acting, and lung‐selective muscarinic cholinergic receptor (mAChR) antagonist in… Expand
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Review
2017
Review
2017
Long acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs
ABSTRACT Introduction: Long acting muscarinic receptor antagonists (LAMA) reverse airflow obstruction by antagonizing para… Expand
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2014
2014
Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Introduction TD-4208 is a lung-selective, LAMA shown to have a long duration of action and minimal systemic antimuscarinic… Expand
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2013
2013
In Vivo Pharmacological Characterization of TD-4208, a Novel Lung-Selective Inhaled Muscarinic Antagonist with Sustained Bronchoprotective Effect in Experimental Animal Models
Tiotropium is currently the only once-daily, long-acting muscarinic antagonist (LAMA) approved in the United States and other… Expand
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Review
2013
Review
2013
Long-acting muscarinic receptor antagonists for the treatment of respiratory disease.
The use of muscarinic receptor antagonists in the treatment of chronic obstructive pulmonary disease (COPD) is well established… Expand
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2012
2012
A randomized, crossover study to examine the pharmacodynamics and safety of a new antimuscarinic (TD-4208) in COPD
Background: TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration in… Expand
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2009
2009
In Vitro Characterization of TD-4208, a Lung-Selective and Long-Acting Muscarinic Antagonist Bronchodilator.
 
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2009
2009
TD-4208: A Novel, Lung-Selective Muscarinic Antagonist with Sustained Bronchoprotective Activity in Preclinical Models.
 
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